{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:35:35Z","timestamp":1787726135152,"version":"build-2784847793"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1038\/ja.2015.118","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T07:20:27Z","timestamp":1449040827000},"page":"403-405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Biosynthetic origin of anthracimycin: a tricyclic macrolide from Streptomyces sp."],"prefix":"10.1038","volume":"69","author":[{"given":"Enjuro","family":"Harunari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"BFja2015118_CR1","unstructured":"Igarashi, Y., Iida, T., Miyanouchi, K. & Sudo, Y. Production of TPU0114. PCT\/JP 2011\/010586."},{"key":"BFja2015118_CR2","unstructured":"Kim, Y., In, Y., Ishida, T., Onaka, H. & Igarashi, Y Biosynthetically unique polyketides from Streptomyces sp. Organ. Comm. 54th Symp. Chem. Nat. Prod. 18 (2012)."},{"key":"BFja2015118_CR3","doi-asserted-by":"publisher","first-page":"7822","DOI":"10.1002\/anie.201302749","volume":"52","author":"KH Jang","year":"2013","unstructured":"Jang, K. H. et al. Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete. Angew. Chem. Int. Ed. 52, 7822\u20137824 (2013).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFja2015118_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/ja.2014.36","volume":"67","author":"ME Hensler","year":"2014","unstructured":"Hensler, M. E. et al. Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. J. Antibiot. 67, 549\u2013553 (2014).","journal-title":"J. Antibiot."},{"key":"BFja2015118_CR5","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/anie.200703993","volume":"47","author":"K Gerth","year":"2008","unstructured":"Gerth, K., Steinmetz, H., H\u00f6fle, G. & Jansen, R. Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, so ce1525. Angew. Chem Int. Ed. 47, 600\u2013602 (2008).","journal-title":"Angew. Chem Int. Ed."},{"key":"BFja2015118_CR6","doi-asserted-by":"publisher","first-page":"4802","DOI":"10.1002\/anie.201107204","volume":"51","author":"JM Finefield","year":"2012","unstructured":"Finefield, J. M., Sherman, D. H., Kreitman, M. & Williams, R. M. Enantiomeric natural products: Occurrence and biogenesis. Angew. Chem. Int. Ed. 51, 4802\u20134836 (2012).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFja2015118_CR7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/hesc\/9780198703419.001.0001","volume-title":"Nuclear magnetic resonance","author":"P Hore","year":"2015","unstructured":"Hore, P. Nuclear magnetic resonance. 2nd edn 34\u201337 Oxford University Press, Oxford, UK, (2015)."},{"key":"BFja2015118_CR8","first-page":"507","volume":"41","author":"A Bax","year":"1980","unstructured":"Bax, A. & Freeman, R. Investigation of 13C-13C couplings in natural abundance samples: The strong coupling case. J. Magn. Reson. 41, 507\u2013511 (1980).","journal-title":"J. Magn. Reson."},{"key":"BFja2015118_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/9780470742761","volume-title":"Medicinal Natural Products: A Biosynthetic Approach","author":"PM Dewick","year":"2009","unstructured":"Dewick, P. M. Medicinal Natural Products: A Biosynthetic Approach. 3rd edn (Wiley & Sons, Hoboken, NJ, USA, (2009)."},{"key":"BFja2015118_CR10","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1021\/ja00405a044","volume":"103","author":"TS Chen","year":"1981","unstructured":"Chen, T. S., Chang, C. J. & Floss, H. G. Biosynthesis of the boron-containing macrolide antibiotic aplasmomycin by Streptomyces griseus. J. Am. Chem. Soc. 103, 4565\u20134568 (1981).","journal-title":"J. Am. Chem. Soc."},{"key":"BFja2015118_CR11","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1021\/jo00326a010","volume":"46","author":"TS Chen","year":"1981","unstructured":"Chen, T. S., Chang, C. J. & Floss, H. G. On the biosynthesis of boromycin. J. Org. Chem. 46, 2661\u20132666 (1981).","journal-title":"J. Org. Chem."},{"key":"BFja2015118_CR12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.7164\/antibiotics.32.414","volume":"32","author":"C-M Liu","year":"1979","unstructured":"Liu, C.-M., Williams, T. H. W. & Pitcher, R. G. P. 13C-NMR studies on the biosynthesis of aurodox (antibiotic X-5108). J. Antibiot. 32, 414\u2013417 (1979).","journal-title":"J. Antibiot."},{"key":"BFja2015118_CR13","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.1016\/S0040-4039(00)85824-4","volume":"23","author":"K Kakinuma","year":"1982","unstructured":"Kakinuma, K., Uzawa, J. & Uramoto, M. Biosynthesis of the 17-membered carbocyclic ring of lankacidin antibiotics. Tetrahedr. Lett. 23, 5303\u20135306 (1982).","journal-title":"Tetrahedr. Lett."},{"key":"BFja2015118_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/ja.2005.28","volume":"58","author":"B Kunze","year":"2005","unstructured":"Kunze, B., Reichenbach, H., M\u00fcller, R. & H\u00f6fle, G. Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity. J. Antibiot. 58, 244\u2013251 (2005).","journal-title":"J. Antibiot."},{"key":"BFja2015118_CR15","doi-asserted-by":"publisher","first-page":"e01149-15","DOI":"10.1128\/genomeA.01149-15","volume":"3","author":"H Komaki","year":"2015","unstructured":"Komaki, H. et al. Draft genome sequence of an anthracimycin-producer, Streptomyces sp. TP-A0875. Genome Announc. 3, e01149-15 (2015).","journal-title":"Genome Announc."}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ja2015118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja2015118","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja2015118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T20:39:14Z","timestamp":1718224754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ja2015118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,2]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["BFja2015118"],"URL":"https:\/\/doi.org\/10.1038\/ja.2015.118","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,2]]},"assertion":[{"value":"31 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}