{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:20:11Z","timestamp":1785252011733,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1038\/ja.2017.98","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T09:42:52Z","timestamp":1504690972000},"page":"1065-1069","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inhibitory effect of obovatol from Magnolia obovata on the Salmonella type III secretion system"],"prefix":"10.1038","volume":"70","author":[{"given":"Won-Sik","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Gyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung-Mog","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-U","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Han","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"BFja201798_CR1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nrmicro1526","volume":"4","author":"GR Cornelis","year":"2006","unstructured":"Cornelis, G. R. The type III secretion injectisome. Nat. Rev. Microbiol. 4, 811\u2013825 (2006).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFja201798_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.bbamcr.2004.03.011","volume":"1694","author":"SY He","year":"2004","unstructured":"He, S. Y., Nomura, K. & Whittam, T. S. Type III protein secretion mechanism in mammalian and plant pathogens. Biochim. Biophys. Acta 1694, 181\u2013206 (2004).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFja201798_CR3","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1128\/MMBR.68.4.771-795.2004","volume":"68","author":"P Ghosh","year":"2004","unstructured":"Ghosh, P. Process of protein transport by the type III secretion system. Microbiol. Mol. Biol. Rev. 68, 771\u2013795 (2004).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"BFja201798_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1128\/JB.01004-08","volume":"191","author":"KJV Andreas","year":"2009","unstructured":"Andreas, K. J. V., Charltta, S. & Ariel, J. B. Small-molecule type III secretion system inhibitors block assembly of the shigella type III secreton. J. Bacteriol. 191, 563\u2013570 (2009).","journal-title":"J. Bacteriol."},{"key":"BFja201798_CR5","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1046\/j.1365-2958.2001.02200.x","volume":"39","author":"A Blocker","year":"2001","unstructured":"Blocker, A. et al. Structure and composition of the shiella flexneri \u2018needle complex\u2019, a part of its type III secretion. Mol. Microbiol. 39, 652\u2013663 (2001).","journal-title":"Mol. Microbiol."},{"key":"BFja201798_CR6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.tibs.2006.02.005","volume":"31","author":"CK Yip","year":"2006","unstructured":"Yip, C. K. & Natalie, C. J. S. New structural insights into the bacterial type III secretion system. Trends Biochem. Sci. 31, 223\u2013230 (2006).","journal-title":"Trends Biochem. Sci."},{"key":"BFja201798_CR7","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nsmb.1599","volume":"16","author":"JL Hodgkison","year":"2009","unstructured":"Hodgkison, J. L. et al. Three-dimensional reconstruction of the shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout. Nat. Struct. Mol. Biol. 16, 477\u2013485 (2009).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFja201798_CR8","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1073\/pnas.0535335100","volume":"100","author":"A Blocker","year":"2003","unstructured":"Blocker, A., Komoriya, K. & Aizawa, S. Type III secretion systems and bacterial flagella: insights into their function from structural similarities. Proc. Natl Acad. Sci. USA 100, 3027\u20133030 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFja201798_CR9","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1128\/IAI.72.7.4004-4009.2004","volume":"72","author":"G Wilharm","year":"2004","unstructured":"Wilharm, G. et al. Yersinia enterocolitica type III secretion depends on the proton motive force but not on the flagellar motor components MotA and MotB. Infect. Immun. 72, 4004\u20134009 (2004).","journal-title":"Infect. Immun."},{"key":"BFja201798_CR10","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-micro-092412-155725","volume":"68","author":"JE Galan","year":"2014","unstructured":"Galan, J. E., Lara-Teiero, M., Marlovits, T. C. & Wagner, S. Bacterial type III secretion system: specialized nanomachines for protein delivery into target cells. Annu. Rev. Microbiol. 68, 415\u2013438 (2014).","journal-title":"Annu. Rev. Microbiol."},{"key":"BFja201798_CR11","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1128\/CMR.00013-07","volume":"20","author":"B Coburn","year":"2007","unstructured":"Coburn, B., Sekirov, I. & Finlay, B. B. Type III secretion systems and disease. Clin. Microbiol. Rev. 20, 535\u2013549 (2007).","journal-title":"Clin. Microbiol. Rev."},{"key":"BFja201798_CR12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","volume":"62","author":"CJ Hueck","year":"1998","unstructured":"Hueck, C. J. Type III protein secretion systems in bacterial pathogens of animals and plants. Microiol. Biol. Rev. 62, 379\u2013433 (1998).","journal-title":"Microiol. Biol. Rev."},{"key":"BFja201798_CR13","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1742-4658.2010.07974.x","volume":"278","author":"PJ Mattel","year":"2011","unstructured":"Mattel, P. J. et al. Membrane targeting and pore formation by the type III secretion system translocon. FEBS J. 278, 414\u2013426 (2011).","journal-title":"FEBS J."},{"key":"BFja201798_CR14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1286-4579(01)01411-3","volume":"3","author":"I Hansen-Wester","year":"2001","unstructured":"Hansen-Wester, I. & Hensel, M. Salmonella pathogenicity islands encoding type III secretion systems. Microbes Infect. 3, 549\u2013559 (2001).","journal-title":"Microbes Infect."},{"key":"BFja201798_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrmicro1788","volume":"6","author":"A Haraga","year":"2008","unstructured":"Haraga, A., Ohlson, M. B. & Miller, S. I. Salmonellae interplay with host cells. Nat. Rev. Microbiol. 6, 53\u201366 (2008).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFja201798_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1146\/annurev.cellbio.17.1.53","volume":"17","author":"JE Galan","year":"2001","unstructured":"Galan, J. E. Salmonella interactions with hose cells: type III secretion at work. Annu. Rev. Cell Dev. Biol. 17, 53\u201386 (2001).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BFja201798_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1128\/CMR.00059-12","volume":"26","author":"A Ceceiro","year":"2013","unstructured":"Ceceiro, A., Tomas, M. & Bou, G. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial. Clin. Microbiol. Rev. 26, 185\u2013230 (2013).","journal-title":"Clin. Microbiol. Rev."},{"key":"BFja201798_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1042\/EBC20160058","volume":"61","author":"EK Schneider","year":"2017","unstructured":"Schneider, E. K., Reyes-Ortega, F. & Velkov, T. Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative \u2018superbug\u2019. Essays Biochem. 61, 115\u2013125 (2017).","journal-title":"Essays Biochem."},{"key":"BFja201798_CR19","first-page":"277","volume":"40","author":"CL Ventola","year":"2015","unstructured":"Ventola, C. L. The antibiotic resistance crisis: part 1: causes and threats. PT 40, 277\u2013283 (2015).","journal-title":"PT"},{"key":"BFja201798_CR20","first-page":"413","volume":"328","author":"A Abe","year":"2005","unstructured":"Abe, A., Matsuzawa, T. & Kuwae, A. Type-III effectors: Sophisticated bacterial virulence factors. Crit. Rev. Biol. 328, 413\u2013428 (2005).","journal-title":"Crit. Rev. Biol."},{"key":"BFja201798_CR21","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1128\/IAI.73.5.3104-3114.2005","volume":"73","author":"R Nordfelth","year":"2005","unstructured":"Nordfelth, R., Kauppi, A. M., Norberg, H. A., Wolf-Watz, H. & Elofsson, M. Small-molecule inhibitors specifically targeting type III secretion. Infect. Immun. 73, 3104\u20133114 (2005).","journal-title":"Infect. Immun."},{"key":"BFja201798_CR22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1517\/14728222.5.3.327","volume":"5","author":"S Muller","year":"2001","unstructured":"Muller, S., Feldman, M. F. & Comelis, G. R. The type III secretion system of gram-negative bacteria: a potential therapeutic target? Expert Opin. Ther. Targets 5, 327\u2013339 (2001).","journal-title":"Expert Opin. Ther. Targets"},{"key":"BFja201798_CR23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/iai.64.4.1085-1092.1996","volume":"64","author":"MR Riesenberg-Wilmes","year":"1996","unstructured":"Riesenberg-Wilmes, M. R., Bearson, B., Foster, J. W. & Curtis, R. 3rd Role of the tolerance response in virulence of Salmonella typhimurium. Infect. Immun. 64, 1085\u20131092 (1996).","journal-title":"Infect. Immun."},{"key":"BFja201798_CR24","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1128\/AAC.01492-06","volume":"55","author":"DL Hudson","year":"2007","unstructured":"Hudson, D. L. et al. Inhibition of type III secretion in Salmonella enteric serovar Typhimurium by small-molecule inhibitors. Antimicrob. Agents Chemother. 55, 2631\u20132635 (2007).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFja201798_CR25","first-page":"293","volume":"41","author":"S Hemaiswarya","year":"2009","unstructured":"Hemaiswarya, S., Raja, R., Anbazhgan, C. & Thiagarajan, V. Antimicrobial and mutagenic properties of the root tubers of Gloriosa superb linn. Pak. J. Bot. 41, 293\u2013299 (2009).","journal-title":"Pak. J. Bot."},{"key":"BFja201798_CR26","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0014-5793(97)00425-0","volume":"410","author":"M Mota-Meira","year":"1997","unstructured":"Mota-Meira, M., Lacroix, C., LaPointe, G. & Lavoie, M. C. Purification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans. FEBS Lett. 410, 275\u2013279 (1997).","journal-title":"FEBS Lett."},{"key":"BFja201798_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1046\/j.1365-2958.1996.00116.x","volume":"22","author":"MW Wood","year":"1996","unstructured":"Wood, M. W., Rosqvist, R., Mulan, P. B., Edwards, M. H. & Galyov, E. E. SopE, a secreted protein of salmonella Dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry. Mol. Microbiol. 22, 327\u2013338 (1996).","journal-title":"Mol. Microbiol."},{"key":"BFja201798_CR28","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1107\/S0907444913002102","volume":"69","author":"VA Meshcheryakov","year":"2013","unstructured":"Meshcheryakov, V. A., Kitoa, A., Matsunami, H. & Samatey, F. A. Inhibition of a type III secretion system by the deletion of a short loop in one its membrane proteins. Acta Crystallogr. D Biol. Crystallogr. 69, 812\u2013820 (2013).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFja201798_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1574-6968.2001.tb10797.x","volume":"202","author":"SI Aizawa","year":"2001","unstructured":"Aizawa, S. I. Bacterial flagella and type III secretion systems. FEMS Microbiol. 202, 157\u2013164 (2001).","journal-title":"FEMS Microbiol."},{"key":"BFja201798_CR30","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1128\/IAI.67.10.5538-5540.1999","volume":"67","author":"J Warawa","year":"1999","unstructured":"Warawa, J., Finlay, B. B. & Kenny, B. Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coli. Infect. Immun. 67, 5538\u20135540 (1999).","journal-title":"Infect. Immun."},{"key":"BFja201798_CR31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.micpath.2004.04.006","volume":"37","author":"T Miki","year":"2004","unstructured":"Miki, T., Okada, N., Shimada, Y. & Danbara, H. Characterization of Salmonella pathogenicity island 1 type III secretion-dependent hemolytic activity in Salmonella enteric serovar Typhimurium. Microb. Pathog. 37, 65\u201372 (2004).","journal-title":"Microb. Pathog."},{"key":"BFja201798_CR32","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1128\/JB.01189-07","volume":"190","author":"TR Field","year":"2008","unstructured":"Field, T. R., Layton, A. N., Bispham, J., Stevens, M. P. & Galyov, E. E. Identification of novel genes and pathway affecting Salmonella type III secretion system 1 using a contact-dependent hemolysis assay. J. Bacteriol. 190, 3393\u20133398 (2008).","journal-title":"J. Bacteriol."},{"key":"BFja201798_CR33","doi-asserted-by":"publisher","first-page":"659","DOI":"10.5551\/jat.7427","volume":"18","author":"ES Park","year":"2011","unstructured":"Park, E. S. et al. Antiplatelet activity of obovatol, a biphenolic component of Magnolia obovata, in rat arterial thrombosis and rabbit platelet aggregation. J. Atheroscler. Thromb. 18, 659\u2013669 (2011).","journal-title":"J. Atheroscler. Thromb."},{"key":"BFja201798_CR34","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/j.1471-4159.2011.07572.x","volume":"120","author":"DY Choi","year":"2012","unstructured":"Choi, D. Y. et al. Obovatol improves cognitive functions in animal models for Alzheimer\u2019s disease. J. Neurochem. 120, 1048\u20131059 (2012).","journal-title":"J. Neurochem."},{"key":"BFja201798_CR35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/jac\/49.1.95","volume":"49","author":"EI Hwang","year":"2002","unstructured":"Hwang, E. I. et al. Obovatols, new chitin synthase 2 inhibitors of Saccharomyces cerevisiae from Magnolia obovata. J. Antimicrob. Chemother. 49, 95\u2013101 (2002).","journal-title":"J. Antimicrob. Chemother."}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ja201798.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ja201798","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ja.2017.98","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/ja201798.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T02:27:14Z","timestamp":1641004034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ja201798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["BFja201798"],"URL":"https:\/\/doi.org\/10.1038\/ja.2017.98","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]},"assertion":[{"value":"25 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}