{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:21:11Z","timestamp":1790864471637,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1981,6,1]],"date-time":"1981-06-01T00:00:00Z","timestamp":360201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:p>\n                    Immobilization stress of conscious, normotensive, freely breathing 10-month-old Wistar-Kyoto rats produced an overall decline in regional cerebral blood flow (rCBF), as measured with [\n                    <jats:sup>14<\/jats:sup>\n                    C]iodoantipyrine, except at the frontal lobe. In 14 brain regions, rCBF fell by an average of 14.3% after 5 min of immobilization and by 11.9% after 15 min. Immobilization stress also stimulated hyperventilation and thereby reduced P\n                    <jats:sub>a<\/jats:sub>\n                    co\n                    <jats:sub>2<\/jats:sub>\n                    . The slope relating rCBF to P\n                    <jats:sub>a<\/jats:sub>\n                    co\n                    <jats:sub>2<\/jats:sub>\n                    averaged 1.5 ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    mm Hg\n                    <jats:sup>\u22121<\/jats:sup>\n                    in 9 significantly affected regions. The findings suggest that rCBF declines during immobilization stress because of cerebrovascular constriction caused by a reduction in P\n                    <jats:sub>a<\/jats:sub>\n                    co\n                    <jats:sub>2<\/jats:sub>\n                    . Comparison of the average slope with published values indicates furthermore that were P\n                    <jats:sub>a<\/jats:sub>\n                    co\n                    <jats:sub>2<\/jats:sub>\n                    to remain unchanged during immobilization, rCBF would increase by at most 20%.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1981.19","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T12:00:25Z","timestamp":1302177625000},"page":"187-194","source":"Crossref","is-referenced-by-count":50,"title":["Effects of Immobilization Stress on Regional Cerebral Blood Flow in the Conscious Rat"],"prefix":"10.1177","volume":"1","author":[{"given":"M.","family":"Ohata","sequence":"first","affiliation":[{"name":"Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. R.","family":"Fredericks","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. I.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1981,6,1]]},"reference":[{"key":"bibr1-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1979.tb06467.x"},{"key":"bibr2-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1975.tb10044.x"},{"key":"bibr3-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90102-0"},{"key":"bibr4-jcbfm.1981.19","first-page":"H690","volume":"234","author":"Chiueh C.C.","year":"1978","journal-title":"Am J Physiol"},{"key":"bibr5-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90863-6"},{"key":"bibr6-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1932.0009"},{"key":"bibr7-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90593-4"},{"key":"bibr8-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.2307\/2332898"},{"key":"bibr9-jcbfm.1981.19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0031-6997(25)06714-6","volume":"28","author":"Edvinsson L.","year":"1977","journal-title":"Pharmacol Rev"},{"key":"bibr10-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012140"},{"key":"bibr11-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1973.tb05489.x"},{"key":"bibr12-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.229.1.113"},{"key":"bibr13-jcbfm.1981.19","first-page":"58","volume":"8","author":"Goodale W.T.","year":"1949","journal-title":"Fed Proc"},{"key":"bibr14-jcbfm.1981.19","volume-title":"The Pharmacological Basis of Therapeutics","author":"Goodman L.S.","year":"1980","edition":"6"},{"key":"bibr15-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.2.150"},{"key":"bibr16-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-021208-1.50044-8"},{"key":"bibr17-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1980.tb06584.x"},{"key":"bibr18-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.18.389"},{"key":"bibr19-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(50)90363-9"},{"key":"bibr20-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102603"},{"key":"bibr21-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1145\/964961.804984"},{"key":"bibr22-jcbfm.1981.19","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.6.6.630"},{"key":"bibr23-jcbfm.1981.19","unstructured":"Miller R.G.Jr (1966) Simultaneous Statistical Inference. 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