{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:10:00Z","timestamp":1791220200525,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:p>\n                    The [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorodeoxyglucose (FDG) scan method with positron emission computed tomography was used to determine patterns of local cerebral glucose utilization (LCMR\n                    <jats:sub>glu<\/jats:sub>\n                    ) in 40 normal volunteer subjects aged 18 to 78 years. Throughout all the studies, each subject was quiet, without movement, with eyes open and ears unplugged, exposed only to ambient room light and sound. For the entire group, whole brain mean CMR\n                    <jats:sub>glu<\/jats:sub>\n                    was 26.1 \u00b1 6.1 \u03bcmol 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (mean \u00b1 SD, n = 40). At age 78, mean CMR glu was, on the average, 26% less than at age 18, an alteration of the same order as the variance among subjects at any age. The gradual decline of mean CMR\n                    <jats:sub>glu<\/jats:sub>\n                    with advancing age occurred at a faster rate than was reported for mean cerebral oxygen utilization, possibly due to increasingly altered pathways for glucose utilization, or to increasing oxidation of ketone bodies or other alternative substrates. Glucose utilization in the hemispheres was symmetrical and mean CMR\n                    <jats:sub>glu<\/jats:sub>\n                    of overall cortex, caudate, and thalamus was equal in individuals at all ages. The slopes of decline with age were similar when LCMR\n                    <jats:sub>glu<\/jats:sub>\n                    was averaged over zones corresponding to centrum semiovale, caudate, putamen, and frontal, temporal, parietal, occipital, and primary visual cortex. However, the metabolic ratio of superior frontal cortex to superior parietal cortex declined with age, possibly due to selective degeneration of superior frontal cortex or to differences between age groups in the sensory and cognitive response to the study. These results should be useful in distinguishing age from disease effects when the FDG scan method is used.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1982.15","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T09:53:54Z","timestamp":1302256434000},"page":"163-171","source":"Crossref","is-referenced-by-count":299,"title":["Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [\n                    <sup>18<\/sup>\n                    F] Fluorodeoxyglucose Method"],"prefix":"10.1177","volume":"2","author":[{"given":"David E.","family":"Kuhl","sequence":"first","affiliation":[{"name":"Laboratory of Nuclear Medicine and the Divisions of Nuclear Medicine and Biophysics of the Department of Radiological Sciences and the Department of Neurology. UCLA School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Jeffrey","family":"Metter","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine and the Divisions of Nuclear Medicine and Biophysics of the Department of Radiological Sciences and the Department of Neurology. UCLA School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Riege","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine and the Divisions of Nuclear Medicine and Biophysics of the Department of Radiological Sciences and the Department of Neurology. UCLA School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Phelps","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine and the Divisions of Nuclear Medicine and Biophysics of the Department of Radiological Sciences and the Department of Neurology. UCLA School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1982,6,1]]},"reference":[{"key":"bibr1-jcbfm.1982.15","first-page":"372","volume":"22","author":"Barrio JR","year":"1981","journal-title":"J Nucl Med"},{"key":"bibr2-jcbfm.1982.15","first-page":"76","volume":"10","author":"Benson DF","year":"1981","journal-title":"Ann Neurol"},{"key":"bibr3-jcbfm.1982.15","first-page":"177","volume-title":"Neurobiology of Aging","author":"Brody H","year":"1976"},{"key":"bibr4-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1159\/000114960"},{"key":"bibr5-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1967.23.2.183"},{"key":"bibr6-jcbfm.1982.15","doi-asserted-by":"crossref","unstructured":"Dastur DK, Lane MH, Hansen DB, Kety SS, Butler RN, Perlin S, Sokoloff L, (1963) Effects of aging on cerebral circulation and metabolism in man. In: Human Aging (Barren JE, Butler RN, Greenhouse SW, Sokoloff L, Yarrow MR, eds), Public Health Service Publication No. 986, pp 59\u201376","DOI":"10.1037\/10776-006"},{"key":"bibr7-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(80)90005-6"},{"key":"bibr8-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198012000-00001"},{"key":"bibr9-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01478536"},{"key":"bibr10-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01484996"},{"key":"bibr11-jcbfm.1982.15","first-page":"54","volume":"60","author":"Gottstein U","year":"1979","journal-title":"Cerebral Blood Flow and Metabolism"},{"key":"bibr12-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1126\/science.6971492"},{"key":"bibr13-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.5"},{"key":"bibr14-jcbfm.1982.15","first-page":"172","volume":"52","author":"Hempel KJ","year":"1968","journal-title":"Dtsch Ges Pathol"},{"key":"bibr15-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-197906000-00001"},{"key":"bibr16-jcbfm.1982.15","first-page":"E69","volume":"238","author":"Huang SC","year":"1980","journal-title":"Am J Physiol"},{"key":"bibr17-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1979.tb02947.x"},{"key":"bibr18-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101994"},{"key":"bibr19-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-009062-7.50026-6"},{"key":"bibr20-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080108"},{"key":"bibr21-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080403"},{"key":"bibr22-jcbfm.1982.15","first-page":"S459","volume":"1","author":"Kuhl DE","year":"1981","journal-title":"J Cereb Blood Flow Metabol"},{"key":"bibr23-jcbfm.1982.15","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/jcbfm.1981.2","volume":"1","author":"Lammertsma AA","year":"1981","journal-title":"J Cereb Blood Flow Metabol"},{"key":"bibr24-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.2.183"},{"key":"bibr25-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.5.503"},{"key":"bibr26-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198110000-00029"},{"key":"bibr27-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120505"},{"key":"bibr28-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.9.921"},{"key":"bibr29-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500130053010"},{"key":"bibr30-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.1.31"},{"key":"bibr31-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500430040005"},{"key":"bibr32-jcbfm.1982.15","first-page":"213","volume-title":"Alzheimer's Disease: Senile Dementia and Related Disorder, Aging","volume":"7","author":"Obrist WD","year":"1978"},{"key":"bibr33-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105650"},{"key":"bibr34-jcbfm.1982.15","first-page":"635","volume":"19","author":"Phelps ME","year":"1978","journal-title":"J Nucl Med"},{"key":"bibr35-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060502"},{"key":"bibr36-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1126\/science.6970412"},{"key":"bibr37-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.5.517"},{"key":"bibr38-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.1.127"},{"key":"bibr39-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(77)90009-4"},{"key":"bibr40-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.2.351"},{"key":"bibr41-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.24.020173.001415"},{"key":"bibr42-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"key":"bibr43-jcbfm.1982.15","first-page":"197","volume-title":"Alzheimer's Disease: Senile Dementia and Related Disorders, Aging","volume":"7","author":"Sokoloff L","year":"1978"},{"key":"bibr44-jcbfm.1982.15","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(81)90020-6"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1982.15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1982.15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:05:51Z","timestamp":1777493151000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1982.15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,6]]}},"alternative-id":["10.1038\/jcbfm.1982.15"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1982.15","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}