{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:07:45Z","timestamp":1777792065641,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1982,6]]},"abstract":"\n The effects of thiamine (B\n 1<\/jats:sub>\n ) deficiency on local CMR\n glu<\/jats:sub>\n (LMCR\n glu<\/jats:sub>\n ) in the vestibular nuclei were studied with the\n 14<\/jats:sup>\n C-2-deoxyglucose autoradiographic method in awake asymptomatic and symptomatic rats. Animals on the B\n 1<\/jats:sub>\n -deficient diet for 98 days developed symptoms of ataxia and opisthotonos. The results show that B\n 1<\/jats:sub>\n deficiency produces: (1) bilateral vestibular nuclei lesions in symptomatic animals; (2) very low LCMR\n glu<\/jats:sub>\n rates in these lesions; and (3) limitation of glial proliferation in the lesions. Giving B\n 1<\/jats:sub>\n to B\n 1<\/jats:sub>\n -deficient symptomatic animals produced a cellular proliferative response consisting mostly of microglia in the lesioned areas of the vestibular nuclei and a high LCMR\n glu<\/jats:sub>\n rate in the regions of microglial proliferation.\n <\/jats:p>","DOI":"10.1038\/jcbfm.1982.20","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T09:53:54Z","timestamp":1302256434000},"page":"203-207","source":"Crossref","is-referenced-by-count":14,"title":["Thiamine Deficiency Limits Glucose Utilization and Glial Proliferation in Brain Lesions of Symptomatic Rats"],"prefix":"10.1177","volume":"2","author":[{"given":"Frank R.","family":"Sharp","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California at San Diego, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Bolger","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California at San Diego, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California at San Diego, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,6,1]]},"reference":[{"key":"bibr1-jcbfm.1982.20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ajcp\/54.2.219","volume":"50","author":"Collins GH","year":"1970","journal-title":"Am J Pathol"},{"key":"bibr2-jcbfm.1982.20","first-page":"791","volume":"50","author":"Collins GH","year":"1967","journal-title":"Am J Pathol"},{"key":"bibr3-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964146"},{"key":"bibr4-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.22.Supplement_13"},{"key":"bibr5-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090404"},{"key":"bibr6-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.17"},{"key":"bibr7-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.22.Supplement_17"},{"key":"bibr8-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb05311.x"},{"key":"bibr9-jcbfm.1982.20","first-page":"564","volume":"66","author":"Manz HJ","year":"1972","journal-title":"Am J Pathol"},{"key":"bibr10-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105912"},{"key":"bibr11-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00592569"},{"key":"bibr12-jcbfm.1982.20","first-page":"223","volume":"25","author":"Peters RS","year":"1969","journal-title":"Br Med J"},{"key":"bibr13-jcbfm.1982.20","first-page":"393","volume":"63","author":"Robertson DM","year":"1971","journal-title":"Am J Pathol"},{"key":"bibr14-jcbfm.1982.20","first-page":"777","volume":"52","author":"Seltzer JL","year":"1974","journal-title":"Am J Physiol"},{"key":"bibr15-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90213-4"},{"key":"bibr16-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"key":"bibr17-jcbfm.1982.20","unstructured":"Victor M, Adams RD, Collins GH, (1971) The Wernicke-Korsakoff Syndrome, Philadelphia, F. 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Davis Company, pp 16\u2013193"},{"key":"bibr18-jcbfm.1982.20","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198107000-00008"}],"container-title":["Journal of Cerebral Blood Flow & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1982.20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1982.20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:05:53Z","timestamp":1777493153000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1982.20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,6]]}},"alternative-id":["10.1038\/jcbfm.1982.20"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1982.20","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}