{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:32:06Z","timestamp":1777793526307,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1983,9,1]],"date-time":"1983-09-01T00:00:00Z","timestamp":431222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>\n                    PN 200\u2013110 [4-(2, 1, 3-benzoxadiazol - 4 -) - 1,4-dihydro - 2,6 - dimethyl - pyridine - 3,5 - dicarboxylic acid methyl 1-methylethyl ester], a new dihydropyridine derivative, was investigated by recording isometric tension on spiral strips from human and canine arteries in tissue baths at 37\u00b0C. Responses to increasing concentrations of CaCl\n                    <jats:sub>2<\/jats:sub>\n                    were investigated in calcium-free depolarizing solution (60 mmol\/L KCl in equimolar replacement for NaCl, 50 mmol\/L TRIZMA buffer, pH 7.4). Comparison of those concentrations that reduced the vasoconstrictor response to 1.6 mmol\/L CaCl\n                    <jats:sub>2<\/jats:sub>\n                    by 50% revealed the following order of potencies on both human and canine arteries: PN 200\u2013110 &gt; nimodipine &gt; nifedipine. Responses to 5-hydroxytryptamine (5-HT) and blood were investigated in Krebs\u2013Henseleit solution (NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    buffer). On canine arteries, PN 200\u2013110 antagonized responses to 5-HT when used at 10\u201330 pmol\/L; it was \u223c70 times more potent on basilar than on mesenteric arteries, whereas both nifedipine and nimodipine were, respectively, \u223c10 and 6 times more potent on basilar than on mesenteric arteries. When canine basilar arteries were constricted by the addition of blood to the organ bath, each of the investigated dihydropyridine derivatives elicited concentration-dependent relaxation, producing the following order of potencies: PN 200\u2013110 &gt; nifedipine = nimodipine. On human anterior cerebral arteries, the blood-induced contractions were counteracted in the following rank order: PN 200\u2013110 = nimodipine &gt; nifedipine. The results suggest that due to its potent calcium-blocking activity on cerebral arteries, PN 200\u2013110 might be of value for the prevention and treatment of cerebrovascular spasms following subarachnoid hemorrhage.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1983.51","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:27:19Z","timestamp":1302269239000},"page":"354-361","source":"Crossref","is-referenced-by-count":47,"title":["<i>in vitro<\/i>\n                    Effects of Calcium Antagonists PN 200-110, Nifedipine, and Nimodipine on Human and Canine Cerebral Arteries"],"prefix":"10.1177","volume":"3","author":[{"given":"E.","family":"M\u00fcller-Schweinitzer","sequence":"first","affiliation":[{"name":"Preclinical Research, Sandoz Ltd., Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Preclinical Research, Sandoz Ltd., Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,9,1]]},"reference":[{"key":"bibr1-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-197901000-00008"},{"key":"bibr2-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-197901000-00007"},{"key":"bibr3-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.4.0433"},{"key":"bibr4-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.4.0442"},{"key":"bibr5-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.4.0451"},{"key":"bibr6-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1976.44.5.0585"},{"key":"bibr7-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1976.44.5.0594"},{"key":"bibr8-jcbfm.1983.51","first-page":"39P","volume":"282","author":"Blaso WP","year":"1978","journal-title":"J Physiol"},{"key":"bibr9-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.606"},{"key":"bibr10-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1977.tb00662.x"},{"key":"bibr11-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.55.2.0237"},{"key":"bibr12-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.37"},{"key":"bibr13-jcbfm.1983.51","first-page":"527","volume-title":"Cerebral Arterial Spasm, Proceedings of the Second International Workshop, Amsterdam, 1979","author":"Cohen RJ","year":"1981"},{"key":"bibr14-jcbfm.1983.51","first-page":"327","volume":"11","author":"Edvinsson L","year":"1979","journal-title":"Surg Neurol"},{"key":"bibr15-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb16744.x"},{"key":"bibr16-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.11.163"},{"key":"bibr17-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.42.4.0420"},{"key":"bibr18-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.3.261"},{"key":"bibr19-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.7.650"},{"key":"bibr20-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1977.46.3.0296"},{"key":"bibr21-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.5.650"},{"key":"bibr22-jcbfm.1983.51","first-page":"338","volume":"32","author":"Towart R","year":"1982","journal-title":"Drug Res"},{"key":"bibr23-jcbfm.1983.51","first-page":"307","volume-title":"Cerebrovascular Diseases (11th Princeton Conference on Cerebrovascular Diseases)","author":"White RP","year":"1979"},{"key":"bibr24-jcbfm.1983.51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp012046"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1983.51","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1983.51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:11:16Z","timestamp":1777493476000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1983.51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1038\/jcbfm.1983.51"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1983.51","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}