{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:36:14Z","timestamp":1777793774905,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>\n                    pH and K\n                    <jats:sup>+<\/jats:sup>\n                    from the extracellular space, PO\n                    <jats:sub>2<\/jats:sub>\n                    , and CBF have been measured in the same region during progressive ischaemia of primate cerebral cortex. As blood flow was reduced, the other changes had the following sequence. PO\n                    <jats:sub>2<\/jats:sub>\n                    fell rapidly to 30% of control levels at regional CBF (rCBF) of 30 ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . As CBF was further reduced, PO\n                    <jats:sub>2<\/jats:sub>\n                    continued to fall. pH remained stable until around 20 ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    , below which pH fell rapidly, with an exponential increase in H\n                    <jats:sup>+<\/jats:sup>\n                    concentration. K\n                    <jats:sup>+<\/jats:sup>\n                    showed the well-known relationship to CBF, remaining normal until around 10 ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    , below which K\n                    <jats:sup>+<\/jats:sup>\n                    rose rapidly. pH\n                    <jats:sub>e<\/jats:sub>\n                    and log K\n                    <jats:sup>+<\/jats:sup>\n                    were linearly related and confirmed that pH fell by 0.3 U before K\n                    <jats:sup>+<\/jats:sup>\n                    rose significantly, and fell by 0.6 U before the massive rise in K\n                    <jats:sup>+<\/jats:sup>\n                    . The mechanisms involved in this sequence of events and the role of pH changes in the development of the so-called \u201cischaemic penumbra\u201d are discussed.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1987.111","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:43:30Z","timestamp":1302223410000},"page":"599-604","source":"Crossref","is-referenced-by-count":51,"title":["pH, K\n                    <sup>+<\/sup>\n                    , and PO\n                    <sub>2<\/sub>\n                    of the Extracellular Space during Ischaemia of Primate Cerebral Cortex"],"prefix":"10.1177","volume":"7","author":[{"given":"R. J.","family":"Harris","sequence":"first","affiliation":[{"name":"Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Richards","sequence":"additional","affiliation":[{"name":"Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Symon","sequence":"additional","affiliation":[{"name":"Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-H.A.","family":"Habib","sequence":"additional","affiliation":[{"name":"Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rosenstein","sequence":"additional","affiliation":[{"name":"Gough Cooper Department of Neurological Surgery, Institute of Neurology, London, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"bibr1-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.76"},{"key":"bibr2-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.1.51"},{"key":"bibr3-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.12.6.723"},{"key":"bibr4-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1038\/273160a0"},{"key":"bibr5-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb05396.x"},{"key":"bibr6-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90112-5"},{"key":"bibr7-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90014-4"},{"key":"bibr8-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1982.11739613"},{"key":"bibr9-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.9"},{"key":"bibr10-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp012038"},{"key":"bibr11-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90231-8"},{"key":"bibr12-jcbfm.1987.111","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1961.200.4.743"},{"key":"bibr13-jcbfm.1987.111","first-page":"88","volume":"33","author":"Erne 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