{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:37:12Z","timestamp":1791077832215,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1987,6,1]],"date-time":"1987-06-01T00:00:00Z","timestamp":549504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:p>\n                    In chloralose-urethanized cats, vasoactive intestinal peptide (VIP), applied by superfusion in steady-state concentration (10\n                    <jats:sup>\u221210<\/jats:sup>\n                    \u201310\n                    <jats:sup>\u22126<\/jats:sup>\n                    M) onto cortical vessels in situ resulted in a rapid concentration-dependent vasodilatation in vessels that were mildly constricted by prostaglandin F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    (PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    ) (5 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    M) or hypocarbia (P\n                    <jats:sub>a<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    = 26). The maximum dilatation produced by VIP (10\n                    <jats:sup>\u22126<\/jats:sup>\n                    M) was about 60% over baseline in pial arteries and 40% in pial veins. Blockade of local neuronal activity with tetrodotoxin (TTX) (10\n                    <jats:sup>\u22125<\/jats:sup>\n                    M) had no effect on the VIP-evoked dilation of pial vessels. Activation of the cortex by either direct electrical stimulation or indirectly by stimulation of the mesencephalic reticular formation (MRF) resulted in a rapid dilatation of pial arterioles and venules. The vasodilatory effects of VIP and of cortical activation via direct cortical stimulation were not blocked by phentolamine (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    M), propranolol (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    M), atropine (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    M), or naloxone (10\n                    <jats:sup>\u22124<\/jats:sup>\n                    M), indicating that the stimulated vasodilatation was not mediated by adrenergic, cholinergic, or opiate receptors. The dilatory effects of MRF, but not direct cortical stimulation, were not blocked by TTX. VIP antiserum (1:25) preincubated in cortical cups had no effect on resting vessel diameter, but resulted in a significant, though subtotal, reduction in the vasodilatation elicited by direct cortical and MRF stimulation. Normal rabbit sera or VIP antiserum preincubated with saturating amounts of VIP were ineffective. In similar experiments, pial arteriolar and venular dilation evoked by hypercarbia was not attenuated by cortically applied VIP antisera. These observations suggest that pial dilation evoked by local increases in neuronal activity may be mediated in part by the local release of VIP from intrinsic neurons. Such a substrate would define a close obligatory coupling between local neuronal activation and local perfusion, such that nutritive flow could be enhanced prior to the onset of any metabolic deficit.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1987.69","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:45:46Z","timestamp":1302223546000},"page":"315-326","source":"Crossref","is-referenced-by-count":40,"title":["Cortical Vasodilatation Produced by Vasoactive Intestinal Polypeptide (VIP) and by Physiological Stimuli in the Cat"],"prefix":"10.1177","volume":"7","author":[{"given":"Tony L.","family":"Yaksh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. L. W.","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mayo Clinic and Foundation, Rochester, Minnesota, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail J.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1987,6,1]]},"reference":[{"key":"bibr1-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66427-4_23"},{"key":"bibr2-jcbfm.1987.69","volume-title":"Proceedings of the Symposium on Cerebral Blood Flow: Effect of Nerves and Neurotransmitters","author":"Bevan JA","year":"1982"},{"key":"bibr3-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90578-3"},{"key":"bibr4-jcbfm.1987.69","first-page":"276","volume":"28","author":"Edvinsson L","year":"1977","journal-title":"Pharmacol Rev"},{"key":"bibr5-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90290-6"},{"key":"bibr6-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307168"},{"key":"bibr7-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013862"},{"key":"bibr8-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014142"},{"key":"bibr9-jcbfm.1987.69","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1038\/jcbfm.1983.30","volume":"3","author":"Edvinsson L","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr10-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(77)90073-8"},{"key":"bibr11-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90535-9"},{"key":"bibr12-jcbfm.1987.69","volume-title":"Biostatistics","author":"Goldstein A","year":"1964"},{"key":"bibr13-jcbfm.1987.69","first-page":"264","volume-title":"Cerebral Function, Metabolism and Circulation","author":"Halsey JH","year":"1977"},{"key":"bibr14-jcbfm.1987.69","first-page":"H73","volume":"239","author":"Heistad DD","year":"1980","journal-title":"Am J Physiol"},{"key":"bibr15-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/97.1.273"},{"key":"bibr16-jcbfm.1987.69","first-page":"14.29","volume-title":"Blood Flow and Metabolism in the Brain","author":"Ingvar DH","year":"1975"},{"key":"bibr17-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(83)90106-5"},{"key":"bibr18-jcbfm.1987.69","first-page":"H371","volume":"234","author":"Kontos HA","year":"1978","journal-title":"Am J Physiol"},{"key":"bibr19-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1968.215.1.90"},{"key":"bibr20-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90951-3"},{"key":"bibr21-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90543-9"},{"key":"bibr22-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719122"},{"key":"bibr23-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90068-X"},{"key":"bibr24-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720370.ch4"},{"key":"bibr25-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.6.711"},{"key":"bibr26-jcbfm.1987.69","first-page":"H449","volume":"238","author":"McCulloch J","year":"1980","journal-title":"Am J Physiol"},{"key":"bibr27-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90763-7"},{"key":"bibr28-jcbfm.1987.69","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/94.4.635"},{"key":"bibr29-jcbfm.1987.69","unstructured":"Owen RM, Dewey JD, Bove AA, (1983) Evaluation of dimensions and steady-state hydraulic properties of coronary arteries. 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