{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:37:29Z","timestamp":1784122649650,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>\n                    The oxygen extraction fraction (OEF) at maximally vasodilated tissue in patients with chronic cerebrovascular disease was evaluated using positron emission tomography. The vascular responsiveness to changes in P\n                    <jats:sub>a<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    was measured by the H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O autoradiographic method. It was correlated with the resting-state OEF, as estimated using the\n                    <jats:sup>15<\/jats:sup>\n                    O steady-state method. The subjects comprised 15 patients with unilateral or bilateral occlusion and stenosis of the internal carotid artery or middle cerebral artery or moyamoya disease. In hypercapnia, the scattergram between the OEF and the vascular responsiveness to changes in P\n                    <jats:sub>a<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    revealed a significant negative correlation in 11 of 19 studies on these patients, and the OEF at the zero cross point of the regression line with a vascular responsiveness of 0 was 0.53 \u00b1 0.08 (n = 11). This OEF in the resting state corresponds to exhaustion of the capacity for vasodilation. The vasodilatory capacity is discussed in relation to the lower limit of autoregulation.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1988.53","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T09:03:47Z","timestamp":1297328627000},"page":"227-235","source":"Crossref","is-referenced-by-count":85,"title":["Oxygen Extraction Fraction at Maximally Vasodilated Tissue in the Ischemic Brain Estimated from the Regional CO\n                    <sub>2<\/sub>\n                    Responsiveness Measured by Positron Emission Tomography"],"prefix":"10.1177","volume":"8","author":[{"given":"Iwao","family":"Kanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schuichi","family":"Higano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsutaro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Shishido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Inugami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Sayama","sequence":"additional","affiliation":[{"name":"Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"bibr1-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.1.21"},{"key":"bibr2-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1159\/000115247"},{"key":"bibr3-jcbfm.1988.53","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/jcbfm.1983.1","volume":"3","author":"Baron JC","year":"1983","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr4-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460210081008"},{"key":"bibr5-jcbfm.1988.53","first-page":"713","volume":"223","author":"Frackowiak RSJ","year":"1985","journal-title":"Q J Med"},{"key":"bibr6-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198012000-00001"},{"key":"bibr7-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90361-1"},{"key":"bibr8-jcbfm.1988.53","first-page":"351","volume":"23","author":"Hagami E","year":"1986","journal-title":"Jpn J Nucl Med"},{"key":"bibr9-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1965.tb01964.x"},{"key":"bibr10-jcbfm.1988.53","first-page":"809","volume":"24","author":"Higano S","year":"1987","journal-title":"Jpn J Nucl Med"},{"key":"bibr11-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1986.99"},{"key":"bibr12-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.60"},{"key":"bibr13-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.4.1.65"},{"key":"bibr14-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-49-580-339"},{"key":"bibr15-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-197902000-00012"},{"key":"bibr16-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.31"},{"key":"bibr17-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198509000-00017"},{"key":"bibr18-jcbfm.1988.53","first-page":"S659","volume":"5","author":"Kanno I","year":"1985","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr19-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.37"},{"key":"bibr20-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.67"},{"key":"bibr21-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.6.711"},{"key":"bibr22-jcbfm.1988.53","doi-asserted-by":"crossref","unstructured":"Miura S, Kanno I, Iida H, Murakami M, Takahashi K, Sasaki H, Inugami A, Shishido F, Ogawa T, Uemura K, (1988) Anatomical adjustment in brain positron emission tomography using x-ray CT images. J Comput Assist Tomogr (in press)","DOI":"10.1097\/00004728-198803000-00038"},{"key":"bibr23-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.2.155"},{"key":"bibr24-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102783"},{"key":"bibr25-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.3.286"},{"key":"bibr26-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.3.361"},{"key":"bibr27-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160504"},{"key":"bibr28-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.89"},{"key":"bibr29-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.609"},{"key":"bibr30-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.19.5.903"},{"key":"bibr31-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090037004"},{"key":"bibr32-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.3.413"},{"key":"bibr33-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.7.5.507"},{"key":"bibr34-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1291"},{"key":"bibr35-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/106.1.197"},{"key":"bibr36-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.25.9"},{"key":"bibr37-jcbfm.1988.53","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1220"},{"key":"bibr38-jcbfm.1988.53","first-page":"1925","volume":"27","author":"Yamamoto S","year":"1986","journal-title":"J Nucl Med"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1988.53","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1988.53","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:21Z","timestamp":1777493541000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1988.53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,4]]}},"alternative-id":["10.1038\/jcbfm.1988.53"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1988.53","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}