{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:37:14Z","timestamp":1777793834998,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1988,2,1]],"date-time":"1988-02-01T00:00:00Z","timestamp":570672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>\n                    In helical strips of dog middle cerebral arteries partially contracted with prostaglandin (PG) F\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    , relaxations induced by angiotensin-II, possibly mediated by PGI\n                    <jats:sub>2<\/jats:sub>\n                    , and those induced by PGH\n                    <jats:sub>2<\/jats:sub>\n                    were reversed to a contraction or markedly reduced by treatment with hemolysate, which, however, attenuated the PGI\n                    <jats:sub>2<\/jats:sub>\n                    -induced relaxation only slightly. The relaxant response of human middle cerebral arterial strips to PGH\n                    <jats:sub>2<\/jats:sub>\n                    was also suppressed by hemolysate. Dog and monkey middle cerebral arteries responded to transmural electrical stimulation and nicotine with transient relaxations, which were quite susceptible to tetrodotoxin and hexamethonium, respectively; the relaxations were abolished almost completely by hemolysate and methylene blue. On the other hand, the relaxant response of dog cerebral arteries to a low concentration of K\n                    <jats:sup>+<\/jats:sup>\n                    was not influenced by hemolysate or by methylene blue, but was reversed to a contraction by treatment with ouabain. Relaxations induced by substance-P and nitroglycerin were markedly inhibited by hemolysate; removal of endothelium abolished the relaxation by substance-P, but did not influence the nitroglycerin-induced relaxation. Hemolysate may interfere with the biosynthesis of PGI\n                    <jats:sub>2<\/jats:sub>\n                    in the vascular wall, thereby reversing the relaxation induced by angiotensin-II and PGH\n                    <jats:sub>2<\/jats:sub>\n                    to a contraction. Relaxations induced by electrical and chemical stimulation of vasodilator nerves innervating cerebral arteries appear to be elicited by a mechanism dependent on cellular cyclic guanosine monophosphate (GMP), like that underlying the substance-P-induced and nitroglycerin-induced relaxation. These actions of hemolysate may be involved in the genesis of cerebral vasospasm after subarachnoid hemorrhage.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1988.7","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:41:18Z","timestamp":1302270078000},"page":"46-53","source":"Crossref","is-referenced-by-count":45,"title":["Hemolysate Inhibits Cerebral Artery Relaxation"],"prefix":"10.1177","volume":"8","author":[{"given":"Noboru","family":"Toda","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Shiga University of Medical Sciences, Seta, Ohtsu, 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