{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:40:56Z","timestamp":1777794056009,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p>\n                    This study documents the effects of an intracarotid artery injection of a lethal threshold amount of KCN (2.5 mg \u00b7 kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) on the energy metabolism and histology of the rat brain. This dose of KCN resulted in a rapid abolition of electroencephalographic activity, which remained essentially absent for up to 3 h. Cerebral metabolite measurements 0.25 h after KCN infusion indicated a 52% reduction in cytochrome oxidase activity, a 600% increase in lactate, a 32% reduction in ATP, a 73% increase in ADP, and an 85% decrease in glycogen. Measurements of the above energy metabolites over the ensuing 7 days showed a return to control of all metabolites by 6\u201324 h. Corresponding to the normalization of energy metabolism was a return of EEG and conscious activity. Histological examination of cyanide-exposed animals revealed a paucity of change with only one animal at 0.5 h showing several dark neurons, two animals at 1 h with minor pallor of corpus callosum and caudate-putamen, and one animal at 48 h with a small hippocampal infarction. It is concluded that it may be impossible to produce a serious enough disruption of cerebral metabolism with KCN injection, to produce neuronal damage by purely \u201chistotoxic\u201d mechanisms.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1989.23","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:43:27Z","timestamp":1302270207000},"page":"156-162","source":"Crossref","is-referenced-by-count":34,"title":["Cerebral Energy Metabolism in Cyanide Encephalopathy"],"prefix":"10.1177","volume":"9","author":[{"given":"V. H.","family":"MacMillan","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"bibr1-jcbfm.1989.23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0021-9258(18)43046-3","volume":"164","author":"Albaum HG","year":"1946","journal-title":"J Biol Chem"},{"key":"bibr2-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-7751-5_12"},{"key":"bibr3-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.2.129"},{"key":"bibr4-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90011-9"},{"key":"bibr5-jcbfm.1989.23","first-page":"91","volume":"492","author":"Demopoulos HB","year":"1980","journal-title":"Acta Physiol Scand [Suppl]"},{"key":"bibr6-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01309.x"},{"key":"bibr7-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.17-1635"},{"key":"bibr8-jcbfm.1989.23","first-page":"111","volume":"49","author":"Hicks SP","year":"1950","journal-title":"Arch Pathol"},{"key":"bibr9-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1948.153.2.348"},{"key":"bibr10-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.7.3.301"},{"key":"bibr11-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1940.22"},{"key":"bibr12-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.9.6.407"},{"key":"bibr13-jcbfm.1989.23","first-page":"306","volume":"67","author":"Levine S","year":"1959","journal-title":"Arch Pathol"},{"key":"bibr14-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195909000-00011"},{"key":"bibr15-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490490054004"},{"key":"bibr16-jcbfm.1989.23","volume-title":"A Flexible System of Enzymatic Analysis","author":"Lowry OH","year":"1972"},{"key":"bibr17-jcbfm.1989.23","first-page":"88","volume-title":"Advances in Perinatal Neurology","author":"Myers RE","year":"1979"},{"key":"bibr18-jcbfm.1989.23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0021-9258(17)30958-4","volume":"167","author":"Olsen NS","year":"1947","journal-title":"J Biol Chem"},{"key":"bibr19-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07567.x"},{"key":"bibr20-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb11170.x"},{"key":"bibr21-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.34"},{"key":"bibr22-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836300"},{"key":"bibr23-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01308.x"},{"key":"bibr24-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110188.ch13"},{"key":"bibr25-jcbfm.1989.23","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967"},{"key":"bibr26-jcbfm.1989.23","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1989.23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1989.23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:46Z","timestamp":1777493566000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1989.23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1038\/jcbfm.1989.23"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1989.23","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}