{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:02:49Z","timestamp":1782763369892,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p>The involvement of perivascular sensory fibers containing substance P (SP) and calcitonin gene-related peptide (CGRP) in the events occurring in conjunction with subarachnoid hemorrhage (SAH) has been studied in a rat model. Two days after blood injection, the time point at which maximum vasoconstriction is occurring in this model, immunocytochemistry and radioimmunoassay showed a reduction in SP- and CGRP-like immunoreactivity (LI). The quantitative measurements revealed a significant 50% reduction of CGRP-LI and a slight reduction of SP-LI in SAH as compared to controls. This partial reduction in neurotransmitter content (denervation) caused no change in the sensitivity of the rat basilar artery to SP or CGRP as studied using a sensitive in vitro method. However, the maximum relaxant response to CGRP was increased from 52 to 81% ( p &lt; 0.05), while there was no change in the maximum SP-induced relaxations. It is suggested that not only a pre-, but also a postsynaptic modulation of perivascular sensory fibers may occur in experimental SAH.<\/jats:p>","DOI":"10.1038\/jcbfm.1990.111","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:02:57Z","timestamp":1302267777000},"page":"602-607","source":"Crossref","is-referenced-by-count":60,"title":["Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage"],"prefix":"10.1177","volume":"10","author":[{"given":"L.","family":"Edvinsson","sequence":"first","affiliation":[{"name":"Departments of Experimental Research, Lund University, Malm\u00f6 General Hospital, Malm\u00f6"},{"name":"Department of Internal Medicine, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Delgado-Zygmunt","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Lund University, Malm\u00f6 General Hospital, Malm\u00f6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ekman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Departments of Experimental Research, Lund University, Malm\u00f6 General Hospital, Malm\u00f6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N-Aa","family":"Svendgaard","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Uddman","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Lund University, Malm\u00f6 General Hospital, Malm\u00f6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1990,9,1]]},"reference":[{"key":"bibr1-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90293-9"},{"key":"bibr2-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"bibr3-jcbfm.1990.111","first-page":"15","volume-title":"Tachykinin Antagonists","author":"Brodin E","year":"1985"},{"key":"bibr4-jcbfm.1990.111","first-page":"399","volume-title":"General Cytochemical Methods","volume":"1","author":"Coons AH","year":"1958"},{"key":"bibr5-jcbfm.1990.111","first-page":"1","volume-title":"An experimental study in the rat","author":"Delgado T","year":"1986"},{"key":"bibr6-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.595"},{"key":"bibr7-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1986.106"},{"key":"bibr8-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90187-3"},{"key":"bibr9-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90166-1"},{"key":"bibr10-jcbfm.1990.111","first-page":"407","volume-title":"Neural Regulation of Brain Circulation","author":"Edvinsson L","year":"1986"},{"key":"bibr11-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.126"},{"key":"bibr12-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(88)90075-4"},{"key":"bibr13-jcbfm.1990.111","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.31"},{"key":"bibr14-jcbfm.1990.111","doi-asserted-by":"crossref","unstructured":"Edvinsson L, Ekman R, Jansen I, Kingman TA, McCulloch J, Uddman R, (1990) Reduced levels of calcitonin gene-related peptide-like immunoreactivity in human brain vessels after subarachnoid haemorrhage. 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