{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:15:34Z","timestamp":1777792534302,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>\n                    To clarify the effect of extracellular magnesium (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ) on the vascular reactivity of feline isolated middle cerebral arteries, the effects of slight alterations in the Mg\n                    <jats:sup>2+<\/jats:sup>\n                    concentration on the contractile and endothelium-dependent dilatory responses were investigated in vitro. The contractions, induced by 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    -10\n                    <jats:sup>\u22125<\/jats:sup>\n                    M norepinephrine, were significantly potentiated at low Mg\n                    <jats:sup>2+<\/jats:sup>\n                    (0.8 m M v. the normal, 1.2 m M). High (1.6 and 2.0 m M) Mg\n                    <jats:sup>2+<\/jats:sup>\n                    exhibited an inhibitory effect on the contractile responses. No significant changes, however, in the EC\n                    <jats:sub>50<\/jats:sub>\n                    values for norepinephrine were found. The endothelium-dependent relaxations induced by 10\n                    <jats:sup>8<\/jats:sup>\n                    \u201310\n                    <jats:sup>\u22125<\/jats:sup>\n                    M acetylcholine were inhibited by high (1.6 and 2.0 m M) Mg\n                    <jats:sup>2+<\/jats:sup>\n                    . Lowering of the Mg\n                    <jats:sup>2+<\/jats:sup>\n                    concentration to 0.8 m M or total withdrawal of this ion from the medium failed to alter the dilatory potency of acetylcholine. The changes in the dilatory responses also shifted the EC\n                    <jats:sub>50<\/jats:sub>\n                    values for acetylcholine to the right. The present results show that the contractile responses of the cerebral arteries are extremely susceptible to the changes of Mg\n                    <jats:sup>2+<\/jats:sup>\n                    concentrations. In response to contractile and endothelium-dependent dilatory agonists, Mg\n                    <jats:sup>2+<\/jats:sup>\n                    probably affects both the calcium influx into the endothelial and smooth muscle cells as well as the binding of acetylcholine to its endothelial receptor. Since Mg\n                    <jats:sup>2+<\/jats:sup>\n                    deficiency might facilitate the contractile but not the endothelium-dependent relaxant responses, the present study supports a role for Mg\n                    <jats:sup>2+<\/jats:sup>\n                    deficiency in the development of the cerebral vasospasm.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1991.20","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:07:19Z","timestamp":1302268039000},"page":"161-164","source":"Crossref","is-referenced-by-count":22,"title":["Contractile and Endothelium-Dependent Dilatory Responses of Cerebral Arteries at Various Extracellular Magnesium Concentrations"],"prefix":"10.1177","volume":"11","author":[{"given":"M\u00e1ria","family":"Farag\u00f3","sequence":"first","affiliation":[{"name":"Experimental Research Department and Second Institute of Physiology, Semmelweis University Medical School, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Experimental Research Department and Second Institute of Physiology, Semmelweis University Medical School, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E\u00f6rs","family":"D\u00f3ra","sequence":"additional","affiliation":[{"name":"Experimental Research Department and Second Institute of Physiology, Semmelweis University Medical School, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Experimental Research Department and Second Institute of Physiology, Semmelweis University Medical School, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisztid G. B.","family":"Kov\u00e1ch","sequence":"additional","affiliation":[{"name":"Experimental Research Department and Second Institute of Physiology, Semmelweis University Medical School, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"bibr1-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.12.2477294"},{"key":"bibr2-jcbfm.1991.20","first-page":"2672","volume":"40","author":"Altura B.M.","year":"1981","journal-title":"Fed Proc"},{"key":"bibr3-jcbfm.1991.20","first-page":"195","volume":"3","author":"Altura B.T.","year":"1984","journal-title":"Magnesium"},{"key":"bibr4-jcbfm.1991.20","first-page":"245","volume":"4","author":"Altura B.M.","year":"1985","journal-title":"Magnesium"},{"key":"bibr5-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1987.tb11235.x"},{"key":"bibr6-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.5.557"},{"key":"bibr7-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.9.2545495"},{"key":"bibr8-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"bibr9-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07178.x"},{"key":"bibr10-jcbfm.1991.20","first-page":"174","volume-title":"Endothelium-Derived Relaxing Factors","author":"Kov\u00e1ch A.G.B.","year":"1990"},{"key":"bibr11-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.32.020181.001333"},{"key":"bibr12-jcbfm.1991.20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1056\/NEJM198601023140108","volume":"314","author":"Scully R.E.","year":"1986","journal-title":"N Engl J Med"},{"key":"bibr13-jcbfm.1991.20","first-page":"19","volume":"4","author":"Singer H.A.","year":"1982","journal-title":"Hypertension"},{"key":"bibr14-jcbfm.1991.20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.001515"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1991.20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1991.20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:07:23Z","timestamp":1777493243000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1991.20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1038\/jcbfm.1991.20"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1991.20","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}