{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:15:52Z","timestamp":1777792552939,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>\n                    Recently, accumulated data have suggested that the nucleus basalis magnocellularis, i.e., the substantia innominata (SI), may represent the primary source of central cholinergic innervation in the rat cortical vasculature. We therefore examined the effects of unilateral lesion of the SI on the autoregulation of local CBF (1CBF) during induced hypotension in rats. Male Wistar rats were divided into three groups. The animals of groups 1 and 2 received an injection of 5 \u03bcg of ibotenate into the right SI stereotaxically. At 7 days after the injection, the 1CBF was measured by the [\n                    <jats:sup>14<\/jats:sup>\n                    C]iodoantipyrine technique in the awake state. Group 1 was used as the normotensive group (MABP = 113.1 \u00b1 12.2 mm Hg). Group 2 formed the hypotensive group, and the 1CBF was measured during hypotension (MABP = 80.0 \u00b1 5.5 mm Hg) induced by hemorrhage. Group 3, the sham-operated normotensive group, received vehicle injection into the right SI at 7 days prior to the 1CBF measurement. In group 1, 1CBF was significantly lower in the frontal, parietal, temporal, and striate cortices on the lesioned side compared to that on the contralateral side. In group 2, 1CBF was significantly decreased in the cortices on the lesioned side, but there was no significant difference in magnitude of the 1CBF reduction between groups 1 and 2. Group 3 exhibited no hemispheric asymmetries in 1CBF. These findings suggest that the SI exerts an influence on cortical 1CBF, but does not play a role in the autoregulation of 1CBF during hypotension.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1991.7","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:07:19Z","timestamp":1302268039000},"page":"66-71","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Lesioning of the Substantia Innominata on Autoregulation of Local Cerebral Blood Flow in Rats"],"prefix":"10.1177","volume":"11","author":[{"given":"Shintaro","family":"Gomi","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kortaro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shutaro","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban","family":"Mihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"bibr1-jcbfm.1991.7","doi-asserted-by":"crossref","first-page":"S517","DOI":"10.1038\/jcbfm.1985.78","volume":"5","author":"Araki N.","year":"1985","journal-title":"J Cereb Blood Flow Metab"},{"key":"bibr2-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902500108"},{"key":"bibr3-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90101-0"},{"key":"bibr4-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1038\/309153a0"},{"key":"bibr5-jcbfm.1991.7","first-page":"117","volume":"200","author":"Edvinsson L.","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr6-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(83)80023-9"},{"key":"bibr7-jcbfm.1991.7","first-page":"527","volume":"25","author":"Gomi S.","year":"1988","journal-title":"Autonom Nerv Syst (Tokyo)"},{"key":"bibr8-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65814-3_12"},{"key":"bibr9-jcbfm.1991.7","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-026821-7.50021-X"},{"key":"bibr10-jcbfm.1991.7","first-page":"47","volume-title":"Handbook of Clinical Neurology, Vol. 53. 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