{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:21:40Z","timestamp":1777792900587,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1992,11,1]],"date-time":"1992-11-01T00:00:00Z","timestamp":720576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:p>\n                    Hemodilution has had limited success as a treatment of cerebral ischemia. When using a nonoxygen binding fluid, the therapeutic efficacy of hemodilution-induced increases in CBF are offset by concomitant decreases in oxygen content. The effect of hemodilution, with diaspirin \u03b1-\u03b1 cross-linked hemoglobin (DCLHb), on CBF during middle cerebral artery occlusion was assessed. Rats were hemodiluted to one of the following hematocrits (Hct): (a) 44\/Hct, (b) 37\/Hct, (c) 30\/Hct, (d) 23\/Hct, (e) 16\/Hct, or (f) 9\/Hct. After 10 min of ischemia, CBF was determined with\n                    <jats:sup>14<\/jats:sup>\n                    C-iodoantipyrine. Coronal brain sections were evaluated for areas with a CBF of 0\u201310 and 11\u201320 ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . In addition, oxygen delivery was calculated. In the center of the ischemic zone, both areas of low CBF were less in the 30\/Hct, 23\/Hct, and 16\/Hct groups compared with the 44\/Hct and 37\/Hct groups; and both areas were less in the 9\/Hct group compared with the other five groups ( p &lt; 0.05). For the hemisphere contralateral to occlusion, there was a direct correlation between hematocrit and oxygen delivery. However, for the hemisphere ipsilateral to occlusion, oxygen delivery increased as hematocrit decreased (44\/Hct, 8.6 \u00b1 0.3 vs. 9\/Hct, 13.6 \u00b1 0.4 [mean \u00b1 SD, ml 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ]). The results of this study support a hypothesis that hemodilution with DCLHb decreases the extent of focal cerebral ischemia.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1992.134","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:10:21Z","timestamp":1302268221000},"page":"971-976","source":"Crossref","is-referenced-by-count":51,"title":["Focal Cerebral Ischemia in Rats: Effect of Hemodilution with \u03b1-\u03b1 Cross-Linked Hemoglobin on CBF"],"prefix":"10.1177","volume":"12","author":[{"given":"Daniel J.","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall M.","family":"Schell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Przybelski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Drummond","sequence":"additional","affiliation":[{"name":"VA Medical Center, San Diego"},{"name":"University of California at San Diego, La Jolla, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,11,1]]},"reference":[{"key":"bibr1-jcbfm.1992.134","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1989.tb01807.x"},{"key":"bibr2-jcbfm.1992.134","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.12.6.723"},{"key":"bibr3-jcbfm.1992.134","first-page":"S458","volume":"11","author":"Back T","year":"1991","journal-title":"J Cereb Blood Flow 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