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N-Methyl-d-aspartate (NMDA), \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate, and kainate toxicities were attenuated in a concentration-dependent fashion by high concentrations of secobarbital or thiopental. Antagonism of NMDA toxicity was not overcome by increasing NMDA concentration and not mimicked by \u03b3-aminobutyrate. Despite these antiexcitotoxic actions, secobarbital exacerbated the neuronal death induced by deprivation of either glucose alone or oxygen and glucose together; death induced by oxygen deprivation alone was little affected. Thiopental and methohexital also increased oxygen-glucose deprivation injury. A possible explanation for this injury potentiation was provided by the observation that secobarbital enhanced the cellular ATP depletion induced by combined oxygen-glucose deprivation. Deleterious effects on ATP production may counterbalance the protective effects of barbiturates under some conditions.<\/jats:p>","DOI":"10.1038\/jcbfm.1993.102","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:13:04Z","timestamp":1302268384000},"page":"803-810","source":"Crossref","is-referenced-by-count":17,"title":["Secobarbital Attenuates Excitotoxicity but Potentiates Oxygen\u2014Glucose Deprivation Neuronal Injury in Cortical Cell Culture"],"prefix":"10.1177","volume":"13","author":[{"given":"Rona G.","family":"Giffard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Stanford University School of Medicine, Stanford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond A.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University 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