{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:45Z","timestamp":1780099245036,"version":"3.54.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>Magnetic susceptibility contrast-enhanced and diffusion-weighted echo planar magnetic resonance (MR) imaging was performed using a cat model of acute regional cerebral ischemia induced by partial stenosis of the right middle cerebral artery (MCA). The imaging data were correlated with triphenyltetrazolium chloride (TTC)-stained histopathologic coronal brain sections to determine the prognostic efficacy of high-speed MR imaging techniques in differentiating mild, moderate, and severe cerebral hypoperfusion. Brains of animals without cortical injury on TTC staining were found to have a reduction in peak contrast enhancement of 32 \u00b1 6% (mean \u00b1 SD) below control values with no significant change in the apparent diffusion coefficient (ADC), determined from the diffusion-weighted MR images. In cases where moderate ischemic injury was observed in the TTC-stained sections, a 10\u201320% drop in the ADC was found over the 6-h study period, accompanied by a much wider variation in peak contrast enhancement. Finally, where TTC staining showed severe ischemic brain damage, a 40\u201350% drop in ADC and a reduction in peak contrast enhancement effect of &gt;95% were observed as early as 1 h following MCA stenosis. The significant correlation between imaging observations and histologically confirmed cerebral ischemia indicates that magnetic susceptibility contrast-enhanced echo planar MR imaging is sensitive to slight reductions in cerebral perfusion that fall below the threshold for reliably detectable ischemia-induced alterations in ADC. First-pass perfusion-sensitive imaging may thus be diagnostically useful in differentiating severely hypoperfused permanently injured tissue from the mildly hypoperfused ischemic penumbra.<\/jats:p>","DOI":"10.1038\/jcbfm.1993.117","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:15:48Z","timestamp":1302268548000},"page":"940-946","source":"Crossref","is-referenced-by-count":80,"title":["High-Speed MR Imaging of Ischemic Brain Injury following Stenosis of the Middle Cerebral Artery"],"prefix":"10.1177","volume":"13","author":[{"given":"T. P. L.","family":"Roberts","sequence":"first","affiliation":[{"name":"Neuroradiology Section, Department of Radiology, University of California at San Francisco, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Vexler","sequence":"additional","affiliation":[{"name":"Neuroradiology Section, Department of Radiology, University of California at San Francisco, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Derugin","sequence":"additional","affiliation":[{"name":"Neuroradiology Section, Department of Radiology, University of California at San Francisco, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Moseley","sequence":"additional","affiliation":[{"name":"Neuroradiology Section, Department of Radiology, University of California at San Francisco, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kucharczyk","sequence":"additional","affiliation":[{"name":"Neuroradiology Section, Department of Radiology, University of California at San Francisco, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,11,1]]},"reference":[{"key":"bibr1-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140311"},{"key":"bibr2-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.1.28"},{"key":"bibr3-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.3.579"},{"key":"bibr4-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.149.1.6310680"},{"key":"bibr5-jcbfm.1993.117","first-page":"105","volume":"2","author":"Choi DW","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"bibr6-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.2.342"},{"key":"bibr7-jcbfm.1993.117","first-page":"58","volume":"2","author":"Ginsberg MD","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"bibr8-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.3.329"},{"key":"bibr9-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140307"},{"key":"bibr10-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198810000-00007"},{"key":"bibr11-jcbfm.1993.117","first-page":"636","volume-title":"Magnetic Resonance Imaging","author":"Jacobs BC","year":"1992"},{"key":"bibr12-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.3.417"},{"key":"bibr13-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.802"},{"key":"bibr14-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.2.268"},{"key":"bibr15-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910190220"},{"key":"bibr16-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140213"},{"key":"bibr17-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3719\/10\/3\/004"},{"key":"bibr18-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910180106"},{"key":"bibr19-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.2.143"},{"key":"bibr20-jcbfm.1993.117","first-page":"423","volume":"11","author":"Moseley ME","year":"1990","journal-title":"AJNR"},{"key":"bibr21-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140218"},{"key":"bibr22-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130103"},{"key":"bibr23-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140211"},{"key":"bibr24-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.20"},{"key":"bibr25-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327492"},{"key":"bibr26-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1063\/1.1695690"},{"key":"bibr27-jcbfm.1993.117","first-page":"577","volume":"2","author":"Truwit CL","year":"1992","journal-title":"Neuroimag Clin North Am"},{"key":"bibr28-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.4.576"},{"key":"bibr29-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910060205"},{"key":"bibr30-jcbfm.1993.117","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880010305"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1993.117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1993.117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:06:17Z","timestamp":1777493177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1993.117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1038\/jcbfm.1993.117"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1993.117","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}