{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:00Z","timestamp":1792804140240,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>\n                    We studied brain energy metabolism by phosphorus magnetic resonance spectroscopy (\n                    <jats:sup>31<\/jats:sup>\n                    P MRS) in 28 patients with mitochondrial cytopathies, and 20 normal control subjects. Fourteen patients had myopathy alone, six had only mild brain symptoms, and eight showed different degrees of brain involvement. Brain\n                    <jats:sup>31<\/jats:sup>\n                    P MRS showed a low phosphocreatine content in all patients, accompanied by a high inorganic phosphate in 14 of 28 patients. The average value of the P\n                    <jats:sub>i<\/jats:sub>\n                    concentration in the patient group was significantly (p = 0.009) different from the control group. The cytosolic pH was normal. From these data were derived a high concentration of ADP (calculated from the creatine kinase equilibrium), a high percent value of V\/V\n                    <jats:sub>max<\/jats:sub>\n                    for ATP biosynthesis, and a low phosphorylation potential, all features showing a derangement of brain energy metabolism, in all patients with mitochondrial cytopathies.\n                    <jats:sup>31<\/jats:sup>\n                    P MRS proved to be sensitive enough to disclose a deficit of mitochondrial functionality not only in the affected patients, but also in those without clinically evident brain symptoms.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1993.61","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T05:50:29Z","timestamp":1305784229000},"page":"469-474","source":"Crossref","is-referenced-by-count":88,"title":["Defective Brain Energy Metabolism Shown by in vivo\n                    <sup>31<\/sup>\n                    P MR Spectroscopy in 28 Patients with Mitochondrial Cytopathies"],"prefix":"10.1177","volume":"13","author":[{"given":"Bruno","family":"Barbiroli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Montagna","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Neurologica dell'Universit\u00e0 di Bologna, Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Neurologica dell'Universit\u00e0 di Bologna, Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Lodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Iotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Cortelli","sequence":"additional","affiliation":[{"name":"Istituto di Clinica Neurologica dell'Universit\u00e0 di Bologna, Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Funicello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Zaniol","sequence":"additional","affiliation":[{"name":"Istituto di Radiologia dell'Universit\u00e0 di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,5,1]]},"reference":[{"key":"bibr1-jcbfm.1993.61","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910070110"},{"key":"bibr2-jcbfm.1993.61","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1990.1005263.x"},{"key":"bibr3-jcbfm.1993.61","first-page":"36","volume":"27","author":"Barbiroli B","year":"1991","journal-title":"Eurospin Q"},{"key":"bibr4-jcbfm.1993.61","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1209"},{"key":"bibr5-jcbfm.1993.61","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010104"},{"key":"bibr6-jcbfm.1993.61","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.5.1231"},{"key":"bibr7-jcbfm.1993.61","first-page":"338","volume":"59","author":"Bottomly PA","year":"1984","journal-title":"J Magn 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