{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:12:46Z","timestamp":1777792366036,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>\n                    Delayed neuronal damage in the ischemic region of the rat brain following middle cerebral artery (MCA) occlusion in stroke-prone spontaneously hypertensive rats was studied. The distribution of neuronal damage was determined by\n                    <jats:sup>45<\/jats:sup>\n                    Ca autoradiography. Accumulation of\n                    <jats:sup>45<\/jats:sup>\n                    Ca was observed in the corpus callosum and ipsilateral cerebral cortex immediately following MCA occlusion. After 3 days of occlusion,\n                    <jats:sup>45<\/jats:sup>\n                    Ca had accumulated in the ipsilateral pyramidal tract, the ventral posterior nucleus of the thalamus, and the lateral portion of the striatum. Significant accumulation of\n                    <jats:sup>45<\/jats:sup>\n                    Ca was observed in the same areas after 7 and 14 days of occlusion. Next the effect of MK-801 on accumulation of\n                    <jats:sup>45<\/jats:sup>\n                    Ca after MCA occlusion was examined using the same technique. MK-801 (0.5\u201310 mg\/kg i.v.) or saline was administered 15 min before MCA occlusion, and volumes of accumulation of\n                    <jats:sup>45<\/jats:sup>\n                    Ca were calculated 1 week after ischemic insults. MK-801 significantly reduced\n                    <jats:sup>45<\/jats:sup>\n                    Ca uptake in the cortex, striatum, and thalamus. Furthermore, there was a strong statistical correlation between the volume of accumulation of\n                    <jats:sup>45<\/jats:sup>\n                    Ca in the cortex and that in the thalamus ( r = 0.8974; p &lt; 0.001; n = 25). We speculate that delayed neuronal damage in the corpus callosum, ipsilateral pyramidal tract, and thalamus may be caused by secondary neuronal degeneration. However, neuronal damage in the striatum, a segment not supplied by the MCA, may be related to excessive release of glutamate.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1994.104","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:18:27Z","timestamp":1302268707000},"page":"831-836","source":"Crossref","is-referenced-by-count":22,"title":["Calcium Accumulation following Middle Cerebral Artery Occlusion in Stroke-Prone Spontaneously Hypertensive Rats"],"prefix":"10.1177","volume":"14","author":[{"given":"Toshiki","family":"Shirotani","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuji","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwako","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Chigasaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"bibr1-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.3.472"},{"key":"bibr2-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85863-5_34"},{"key":"bibr3-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-01-00311.1990"},{"key":"bibr4-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.127"},{"key":"bibr5-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-02-00357.1987"},{"key":"bibr6-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.6.855"},{"key":"bibr7-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.4.605"},{"key":"bibr8-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb12825.x"},{"key":"bibr9-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.10.1485"},{"key":"bibr10-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12371.x"},{"key":"bibr11-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb05352.x"},{"key":"bibr12-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.5.790"},{"key":"bibr13-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1021\/jm00119a001"},{"key":"bibr14-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1007\/BF01104030"},{"key":"bibr15-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90128-0"},{"key":"bibr16-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.8.1037"},{"key":"bibr17-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90690-D"},{"key":"bibr18-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293954"},{"key":"bibr19-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90082-F"},{"key":"bibr20-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190202"},{"key":"bibr21-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.4.575"},{"key":"bibr22-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1126\/science.386513"},{"key":"bibr23-jcbfm.1994.104","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.6"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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