{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:42:07Z","timestamp":1791031327352,"version":"4.1.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>\n                    The cerebral metabolic rate for glucose (CMR\n                    <jats:sub>g1<\/jats:sub>\n                    ) and cerebral energy utilization (CEU) were assessed in immature rats during recovery from cerebral hypoxia\u2013ischemia. CMR\n                    <jats:sub>g1<\/jats:sub>\n                    was determined using a modification of the Sokoloff technique with 2-deoxy-[\n                    <jats:sup>14<\/jats:sup>\n                    C]glucose (2-DG) as the radioactive tracer. CEU was determined using the Lowry decapitation technique. Seven-day postnatal rats underwent unilateral common carotid artery ligation, followed 4 h thereafter by exposure to 8% oxygen at 37\u00b0C for 3 h. At 1, 4, or 24 h of recovery, the rat pups underwent those procedures necessary for the measurement of either CMR\n                    <jats:sub>g1<\/jats:sub>\n                    or CEU. At 1 h of recovery, the CMR\n                    <jats:sub>g1<\/jats:sub>\n                    of the cerebral hemisphere ipsilateral to the carotid artery occlusion was 97% of the control rate (8.7 \u03bcmol 100 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) but was only 48% of the control in the contralateral hemisphere. At 4 h of recovery, the CMR\n                    <jats:sub>g1<\/jats:sub>\n                    was increased 49% above baseline in the ipsilateral hemisphere, decreasing thereafter to 84% of the control at 24 h. The CMR\n                    <jats:sub>g1<\/jats:sub>\n                    of the contralateral hemisphere normalized by 4 h of recovery. An inverse correlation between endogenous concentrations of ATP or phosphocreatine and CMR\n                    <jats:sub>g1<\/jats:sub>\n                    in the ipsilateral hemisphere was apparent at 4 h of recovery. CEU in the ipsilateral cerebral hemisphere was 64 and 46% of the control (3.47 mmol \u223cP\/kg\/min) at 1 and 24 h, respectively (p &lt; 0.05) and 77% of the control at 4 h of recovery. CEU in the contralateral hemisphere was unchanged from the control at all measured intervals. Correlation of the alterations in CMR\n                    <jats:sub>g1<\/jats:sub>\n                    with those in CEU at the same intervals indicated that substrate supply exceeds energy utilization during early recovery from hypoxia-ischemia. The discrepancy combined with a persistent disruption of the cerebral energy state implies the existence of an uncoupling of mitochondrial oxidative phosphorylation as one mechanism for the occurrence of perinatal hypoxic-ischemic brain damage.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1994.35","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:17:58Z","timestamp":1302268678000},"page":"279-288","source":"Crossref","is-referenced-by-count":89,"title":["Cerebral Glucose and Energy Utilization during the Evolution of Hypoxic\u2014Ischemic Brain Damage in the Immature Rat"],"prefix":"10.1177","volume":"14","author":[{"given":"Robert C.","family":"Vannucci","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Pediatric Neurology), The Pennsylvania State University School of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jermone Y.","family":"Yager","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Pediatric Neurology), The Pennsylvania State University School of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Vannucci","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Pediatric Neurology), The Pennsylvania State University School of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"bibr1-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.s3-11.1.155"},{"key":"bibr2-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689000"},{"key":"bibr3-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb32913.x"},{"key":"bibr4-jcbfm.1994.35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.36.1.1","volume":"36","author":"Chen R","year":"1986","journal-title":"Neurology"},{"key":"bibr5-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.4.568"},{"key":"bibr6-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1980.tb02996.x"},{"key":"bibr7-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb03657.x"},{"key":"bibr8-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb11875.x"},{"key":"bibr9-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb01757.x"},{"key":"bibr10-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1966.tb07512.x"},{"key":"bibr11-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1042\/bj1220013"},{"key":"bibr12-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1159\/000240556"},{"key":"bibr13-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1967.tb09564.x"},{"key":"bibr14-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080310"},{"key":"bibr15-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(69)90253-8"},{"key":"bibr16-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1042\/bj0610080"},{"key":"bibr17-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb07709.x"},{"key":"bibr18-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.12.1197"},{"key":"bibr19-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90050-1"},{"key":"bibr20-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)96616-0"},{"key":"bibr21-jcbfm.1994.35","volume-title":"A Flexible System of Enzymatic Analysis","author":"Lowry OH","year":"1972"},{"key":"bibr22-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51740-3"},{"key":"bibr23-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198705000-00010"},{"key":"bibr24-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.3.523"},{"key":"bibr25-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90188-2"},{"key":"bibr26-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1968.tb11627.x"},{"key":"bibr27-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1976.230.3.619"},{"key":"bibr28-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90329-8"},{"key":"bibr29-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199005000-00007"},{"key":"bibr30-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.8.1210"},{"key":"bibr31-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.39"},{"key":"bibr32-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199004000-00003"},{"key":"bibr33-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1982.19"},{"key":"bibr34-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110510"},{"key":"bibr35-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130103"},{"key":"bibr36-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.10.4.437"},{"key":"bibr37-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"bibr38-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90103-P"},{"key":"bibr39-jcbfm.1994.35","volume-title":"Brain Energy Metabolism","author":"Siesj\u00f6 BK","year":"1978"},{"key":"bibr40-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.18"},{"key":"bibr41-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb01001.x"},{"key":"bibr42-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"key":"bibr43-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.31"},{"key":"bibr44-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.76"},{"key":"bibr45-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310141"},{"key":"bibr46-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199004000-00001"},{"key":"bibr47-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1974.226.4.933"},{"key":"bibr48-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(92)90045-Z"},{"key":"bibr49-jcbfm.1994.35","first-page":"264","volume-title":"Cerebral Metabolism and Neural Function","author":"Vannucci RC","year":"1980"},{"key":"bibr50-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.2.245"},{"key":"bibr51-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198909000-00011"},{"key":"bibr52-jcbfm.1994.35","first-page":"155","volume":"18","author":"Vannucci SJ","year":"1992","journal-title":"Soc Neurosci Abstr"},{"key":"bibr53-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(93)90006-X"},{"key":"bibr54-jcbfm.1994.35","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1982.22"},{"key":"bibr55-jcbfm.1994.35","first-page":"459","volume-title":"Methods of Enzymatic Analysis","author":"Williamson DH","year":"1963"},{"key":"bibr56-jcbfm.1994.35","first-page":"H1102","volume":"261","author":"Yager JY","year":"1991","journal-title":"Am J Physiol"},{"key":"bibr57-jcbfm.1994.35","doi-asserted-by":"crossref","first-page":"H672","DOI":"10.1152\/ajpcell.1992.262.3.C672","volume":"262","author":"Yager JY","year":"1992","journal-title":"Am J Physiol"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.35","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.35","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:06:40Z","timestamp":1777493200000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1994.35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1038\/jcbfm.1994.35"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1994.35","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}