{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:44:51Z","timestamp":1778136291423,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>The brain uptake index for vitamin E has not been reported previously. This study examined the possible involvement of altered brain vitamin E uptake as an explanation of alterations in vitamin E levels in the brain following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. The brain uptake index of vitamin E was evaluated in control mice and at 1 and 24 h after toxin treatment. Control mice had a brain uptake index of 6.1 \u00b1 1.2. The toxin induced more than a twofold increase in the vitamin E brain uptake index to 15.2 \u00b1 6.8 at 1 h after treatment, which returned to control values at 24 h. The dramatic increase in the brain uptake index of vitamin E may explain the increases in vitamin E levels found in some brain regions following MPTP administration.<\/jats:p>","DOI":"10.1038\/jcbfm.1994.46","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:17:58Z","timestamp":1302268678000},"page":"362-363","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin E Uptake into the Brain and 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Toxicity"],"prefix":"10.1177","volume":"14","author":[{"suffix":"Jr.","given":"James D.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, Los Angeles, California, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"bibr1-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(91)90006-8"},{"key":"bibr2-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1007\/BF03159937"},{"key":"bibr3-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.3.233"},{"key":"bibr4-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90665-V"},{"key":"bibr5-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-7757-7_4"},{"key":"bibr6-jcbfm.1994.46","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198102263040902"},{"key":"bibr7-jcbfm.1994.46","first-page":"R634","volume":"247","author":"Ziylan YZ","year":"1984","journal-title":"Am J Physiol"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.46","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:06:44Z","timestamp":1777493204000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1994.46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1038\/jcbfm.1994.46"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1994.46","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}