{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:12:31Z","timestamp":1777792351845,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1994,7]]},"abstract":"\n 19<\/jats:sup>\n F magnetic resonance imaging techniques were used to determine \u201cwash-in\u201d and \u201cwash-out\u201d curves of the inert, diffusible gas CHF\n 3<\/jats:sub>\n from 0.4-cc voxels in the cat brain, and mass spectrometer gas detection was used to determine the CHF\n 3<\/jats:sub>\n concentration in expired air. These two sets of data were used to calculate cerebral blood flow values in the 0.4-cc voxels, and the blood flow images were registered with high-resolution\n 1<\/jats:sup>\n H magnetic resonance images. Data were collected both during the wash-in and wash-out phases of the experiment, but the two sets of data were analyzed separately to obtain independent estimates of the blood flow during the two phases, i.e., Q\n in<\/jats:sub>\n and Q\n out<\/jats:sub>\n . Repeated determinations of cerebral blood flow images were performed in individual animals, and the entire protocol was repeated on five different animals. The average values of Q\n in<\/jats:sub>\n and Q\n out<\/jats:sub>\n for a typical 0.4-cc voxel in the parietal cortex were 83 ml 100 g\n \u22121<\/jats:sup>\n min\n \u22121<\/jats:sup>\n and 72 ml 100 g\n \u22121<\/jats:sup>\n min\n \u22121<\/jats:sup>\n , respectively. Monte Carlo calculations utilizing the noise in the\n 19<\/jats:sup>\n F NMR signal from this voxel predict an average standard deviation for Q\n in<\/jats:sub>\n and Q\n out<\/jats:sub>\n of \u00b1 10%. The average standard deviation for repeated measurements (in the same animal) of Q\n in<\/jats:sub>\n and Q\n out<\/jats:sub>\n in this voxel was \u00b1 14%. We conclude that\n 19<\/jats:sup>\n F magnetic resonance imaging approaches have the potential to image cerebral blood flow in humans.\n <\/jats:p>","DOI":"10.1038\/jcbfm.1994.82","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:16:44Z","timestamp":1302268604000},"page":"656-663","source":"Crossref","is-referenced-by-count":14,"title":["19<\/sup>\n F Magnetic Resonance Imaging of Cerebral Blood Flow with 0.4-cc Resolution"],"prefix":"10.1177","volume":"14","author":[{"given":"J.","family":"Pekar","sequence":"first","affiliation":[{"name":"Laboratory for Diagnostic Radiology Research National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ligeti","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD, U.S.A."},{"name":"Semmelweis Medical University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sinnwell","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T. W.","family":"Moonen","sequence":"additional","affiliation":[{"name":"National Center for Research Resources, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Frank","sequence":"additional","affiliation":[{"name":"Laboratory for Diagnostic Radiology Research National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"bibr1-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.122"},{"key":"bibr2-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910280105"},{"key":"bibr3-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.11.3523"},{"key":"bibr4-jcbfm.1994.82","unstructured":"Chen C-N, Hoult D, (1989) Biomedical Magnetic Resonance Technology. Bristol: Adam Hilger, p 131"},{"key":"bibr5-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910150106"},{"key":"bibr6-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910070404"},{"key":"bibr7-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.1.100"},{"key":"bibr8-jcbfm.1994.82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)07246-1","volume":"3","author":"Kety S","year":"1951","journal-title":"Pharmacol Rev"},{"key":"bibr9-jcbfm.1994.82","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910160316"}],"container-title":["Journal of Cerebral Blood Flow & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.82","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1994.82","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:06:54Z","timestamp":1777493214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1994.82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1038\/jcbfm.1994.82"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1994.82","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}