{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:16:30Z","timestamp":1777792590032,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>\n                    Two-, three-, four-, five-, and twelve-week-old gerbils were subjected to various periods of bilateral carotid occlusion (BCO). Rectal and cranial temperatures were maintained at 37\u00b0C during BCO, and only rectal temperature was monitored for 30 min of reperfusion. Seven days after ischemia, animals were perfusion-fixed and the neuronal densities in the hippocampal CA1 sub-fields were counted. The extent of cerebral ischemia during BCO was evaluated with [\n                    <jats:sup>14<\/jats:sup>\n                    C]iodoantipyrine autoradiography. The rectal temperature spontaneously fell to 33\u201334\u00b0C during reperfusion in 2-week-old gerbils, although animals over 3 weeks old presented postischemic hyperthermia. Two-week-old animals therefore were divided into three experimental groups: In one group (2-week-old group I) rectal temperature was not regulated during 30 min of reperfusion, while in the other two groups (2-week-old groups II and III) rectal temperature was regulated at 37 and 38\u00b0C, respectively, during reperfusion. Five-minute BCO produced almost complete destruction of the CA1 neurons in 12-week-old animals. In contrast, most CA1 neurons survived 30 min of BCO in 2-week-old group I and 15 min of BCO in 2-week-old groups II and III. [\n                    <jats:sup>14<\/jats:sup>\n                    C]Iodoantipyrine autoradiography revealed that BCO produced severe forebrain ischemia in 2-week-old gerbils as well as in 12-week-old gerbils. These findings indicate that developing gerbils have a greater tolerance to cerebral ischemia and that such ischemic tolerance is not due to a collateral network between the vertebrobasilar and the carotid circulations previously reported to develop more abundantly in developing gerbils.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1995.110","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:21:16Z","timestamp":1302268876000},"page":"886-891","source":"Crossref","is-referenced-by-count":20,"title":["Resistance to Cerebral Ischemia in Developing Gerbils"],"prefix":"10.1177","volume":"15","author":[{"given":"Masayuki","family":"Kusumoto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University, 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