{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:14:14Z","timestamp":1777792454375,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>\n                    Local cerebral blood flow (lCBF) was measured with [\n                    <jats:sup>14<\/jats:sup>\n                    C]iodoantipyrine in conscious, unrestrained rats during electrical stimulation of the fastigial nucleus (FN). Electrode position in the FN was determined by blood pressure (MABP) responses to stimulation under anesthesia. In nine rats in which MABP responses had been variable under anesthesia, bipolar stimulation (50 Hz, 0.5 ms, 1 s on\/1 s off) with currents of 30\u2013100 \u03bcA after recovery from anesthesia produced stereotypic behavior but little effect on MABP and lCBF. In seven other conscious rats currents could be raised to 75\u2013200 \u03bcA without inducing seizures, resulting in sustained MABP elevations during the lCBF measurement and significantly increased lCBF in the sensory-motor (+ 45%), parietal (+ 31%), and frontal cortices (+ 56%) and the caudate-putamen (+ 27%) above control values ( n = 9). Glucose utilization, measured with [\n                    <jats:sup>14<\/jats:sup>\n                    C]deoxyglucose, in rats similarly stimulated was significantly increased in six structures, including some of the above, indicating increases in lCBF due to metabolic activation. Unilateral or bilateral electrolytic lesions of the FN, placed 6\u20137 days before lCBF measurement, had negligible effects on resting lCBF and on autoregulation in conscious rats. These results fail to support a specific role for the FN in physiological regulation of cerebral blood flow in unanesthetized rats.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1995.15","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:19:26Z","timestamp":1302268766000},"page":"128-142","source":"Crossref","is-referenced-by-count":6,"title":["Role of the Cerebellar Fastigial Nucleus in the Physiological Regulation of Cerebral Blood Flow"],"prefix":"10.1177","volume":"15","author":[{"given":"Shinichi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Crane","sequence":"additional","affiliation":[{"name":"Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland, 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