{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:15:50Z","timestamp":1777792550900,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>\n                    Basic fibroblast growth factor (bFGF) is a polypeptide growth factor that promotes neuronal survival. We recently found that systemic administration of bFGF protects against both excitotoxicity and hypoxia\u2013ischemia in neonatal animals. In the present study, we examined whether systemically administered bFGF could prevent neuronal death induced by intrastriatal injection of N-methyl-d-aspartate (NMDA) or chemical hypoxia induced by intrastriatal injection of malonate in adult rats and 1-methyl-4-phenylpyridinium (MPP\n                    <jats:sup>+<\/jats:sup>\n                    ) in neonatal rats. Systemic administration of bFGF (100 \u03bcg\/kg) for three doses both before and after intrastriatal injection of either NMDA or malonate in adult rats produced a significant neuroprotective effect. In neonatal rats, bFGF produced dose-dependent significant neuroprotective effects against MPP\n                    <jats:sup>+<\/jats:sup>\n                    neurotoxicity, with a maximal protection of \u223c50% seen with either a single dose of bFGF of 300 \u03bcg\/kg or three doses of 100 \u03bcg\/kg. These results show that systemic administration of bFGF is effective in preventing neuronal injury under circumstances in which the blood\u2013brain barrier may be compromised, raising the possibility that this strategy could be effective in stroke.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.1995.76","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T13:18:52Z","timestamp":1302268732000},"page":"619-623","source":"Crossref","is-referenced-by-count":67,"title":["Basic Fibroblast Growth Factor Protects against Excitotoxicity and Chemical Hypoxia in Both Neonatal and Adult Rats"],"prefix":"10.1177","volume":"15","author":[{"given":"Pamela B.","family":"Kirschner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Henshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Weise","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, CNS Growth Factor Research Laboratory, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Trubetskoy","sequence":"additional","affiliation":[{"name":"Center for Imaging and Pharmaceutical Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Finklestein","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, CNS Growth Factor Research Laboratory, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"bibr1-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03633.x"},{"key":"bibr2-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10237"},{"key":"bibr3-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-10-04220.1993"},{"key":"bibr4-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90347-3"},{"key":"bibr5-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90400-4"},{"key":"bibr6-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90104-H"},{"key":"bibr7-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199304000-00006"},{"key":"bibr8-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490250313"},{"key":"bibr9-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350413"},{"key":"bibr10-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1038\/364535a0"},{"key":"bibr11-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-03034.1993"},{"key":"bibr12-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-11-03728.1989"},{"key":"bibr13-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1066"},{"key":"bibr14-jcbfm.1995.76","first-page":"1644","volume":"19","author":"Morita Y","year":"1993","journal-title":"Soc Neurosci Abst"},{"key":"bibr15-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.27"},{"key":"bibr16-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90788-J"},{"key":"bibr17-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-06-01912.1990"},{"key":"bibr18-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90855-4"},{"key":"bibr19-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb11409.x"},{"key":"bibr20-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(92)90190-3"},{"key":"bibr21-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(93)90098-U"},{"key":"bibr22-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10080.x"},{"key":"bibr23-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.372"},{"key":"bibr24-jcbfm.1995.76","first-page":"95","volume":"165","author":"Wagner JA","year":"1991","journal-title":"Curr Top Microbiol Immunol"},{"key":"bibr25-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02618.1988"},{"key":"bibr26-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.90"},{"key":"bibr27-jcbfm.1995.76","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.51"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1995.76","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.1995.76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:07:25Z","timestamp":1777493245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.1995.76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1038\/jcbfm.1995.76"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.1995.76","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}