{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:48Z","timestamp":1791308328375,"version":"4.3.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>\n                    Chronic stroke is a highly important but under-investigated scientific problem in neurologic research. We have reported earlier that stem cell factor (SCF) in combination with granulocyte-colony stimulating factor (G-CSF) treatment during chronic stroke improves functional outcomes. Here we have determined the contribution of bone marrow-derived cells in angiogenesis and neurogenesis, which are enhanced by SCF + G-CSF treatment during chronic stroke. Using bone marrow tracking, flow cytometry, 2-photon live brain imaging, and immunohistochemistry, we observed that the levels of circulating bone marrow stem cells (BMSCs) (CD34\n                    <jats:sup>+<\/jats:sup>\n                    \/c-kit\n                    <jats:sup>+<\/jats:sup>\n                    ) were significantly increased by SCF +G-CSF treatment. In addition, live brain imaging revealed that numerous bone marrow-derived cells migrate into the brain parenchyma in the treated mice. We also found that bone marrow-derived cells, bone marrow-derived endothelial cells, vascular density, and bone marrow-derived neurons were significantly augmented by SCF + G-CSF. It is interesting that, in addition to the increase in bone marrow-derived endothelial cells, the number of bone marrow-derived pericytes was reduced after SCF + G-CSF treatment during chronic stroke. These data suggest that SCF + G-CSF treatment can enhance repair of brain damage during chronic stroke by mobilizing BMSCs, and promoting the contribution of bone marrow-derived cells to angiogenesis and neurogenesis.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2008.168","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T04:00:50Z","timestamp":1234324850000},"page":"759-770","source":"Crossref","is-referenced-by-count":42,"title":["The Role of Stem Cell Factor and Granulocyte-Colony Stimulating Factor in Brain Repair during Chronic Stroke"],"prefix":"10.1177","volume":"29","author":[{"given":"Chun-Shu","family":"Piao","sequence":"first","affiliation":[{"name":"Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E","family":"Gonzalez-Toledo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Qiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ming","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Neil","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ru","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"},{"name":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"bibr1-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"bibr2-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"bibr3-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1215\/S1152851705000232"},{"key":"bibr4-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1775"},{"key":"bibr5-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508033330503"},{"key":"bibr6-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20845"},{"key":"bibr7-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16102-3"},{"key":"bibr8-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8004"},{"key":"bibr9-jcbfm.2008.168","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.12.3795.3795"},{"key":"bibr10-jcbfm.2008.168","first-page":"1","volume":"55","author":"Galli 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