{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:01:32Z","timestamp":1793962892600,"version":"4.8.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Stroke induced by middle cerebral artery occlusion leads to transiently increased progenitor proliferation in the subventricular zone (SVZ) and long-lasting striatal neurogenesis in adult rodents. Tumor necrosis factor-\u03b1 (TNF-\u03b1) is upregulated in stroke-damaged brain. Whether TNF-\u03b1 and its receptors influence SVZ progenitor proliferation after stroke is unclear. Here we show that the increased proliferation 1 week after stroke occurred concomitantly with elevated microglia numbers and TNF-\u03b1 and TNF receptor-1 (TNF-R1) gene expression in the SVZ of wild-type mice. TNF receptor-1 was expressed on sorted SVZ progenitor cells from nestin-green fluorescent protein reporter mice. In animals lacking TNF-R1, stroke-induced SVZ cell proliferation and neuroblast formation were enhanced. In contrast, deletion of TNF-R1 did not alter basal or status epilepticus-stimulated cell proliferation in SVZ. Addition of TNF-\u03b1 reduced the size and numbers of SVZ neurospheres through a TNF-R1-dependent mechanism without affecting cell survival. Our results provide the first evidence that TNF-R1 is a negative regulator of stroke-induced SVZ progenitor proliferation. Blockade of TNF-R1 signaling might be a novel strategy to promote the proliferative response in SVZ after stroke.<\/jats:p>","DOI":"10.1038\/jcbfm.2008.47","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T04:14:52Z","timestamp":1211343292000},"page":"1574-1587","source":"Crossref","is-referenced-by-count":91,"title":["Suppression of Stroke-Induced Progenitor Proliferation in Adult Subventricular Zone by Tumor Necrosis Factor Receptor 1"],"prefix":"10.1177","volume":"28","author":[{"given":"Robert E","family":"Iosif","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology Wallenberg Neuroscience Center, University Hospital, Lund, Sweden"},{"name":"Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ahlenius","sequence":"additional","affiliation":[{"name":"Laboratory of 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