{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:38:02Z","timestamp":1791045482194,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n                    Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) with image acquisition at multiple inversion times is a noninvasive ASL technique able to compensate for spatial heterogeneities in transit times caused by collateral blood flow in patients with severe stenosis of the cerebropetal blood vessels. Our aim was to compare ASL-MRI and H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O positron emission tomography (PET), the gold standard for cerebral blood flow (CBF) assessment, in patients with a symptomatic internal carotid artery (ICA) occlusion. Fourteen patients (63\u00b114 years) with a symptomatic ICA occlusion underwent both ASL-MRI and H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O PET. The ASL-MRI was performed using a pulsed STAR labeling technique at multiple inversion times within 7 days of the PET. The CBF was measured in the gray-matter of the anterior, middle and posterior cerebral artery, and white-matter. Both PET and ASL-MRI showed a significantly decreased CBF in the gray-matter of the middle cerebral artery in the hemisphere ipsilateral to the ICA occlusion. The average gray-matter CBF measured with ASL-MRI (71.8\u00b14.3 mL\/min\/100 g) was higher ( P&lt;0.01) than measured with H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O PET (43.1\u00b11.0 mL\/min\/100 g). In conclusion, ASL-MRI at multiple TIs is capable of depicting areas of regions with low CBF in patients with an occlusion of the ICA, although a systematic overestimation of CBF relative to H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O PET was noted.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2009.204","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T04:00:49Z","timestamp":1254888049000},"page":"222-229","source":"Crossref","is-referenced-by-count":121,"title":["Arterial Spin Labeling Perfusion MRI at Multiple Delay Times: A Correlative Study with H\n                    <sub>2<\/sub>\n                    <sup>15<\/sup>\n                    O Positron Emission Tomography in Patients with Symptomatic Carotid Artery Occlusion"],"prefix":"10.1177","volume":"30","author":[{"given":"Reinoud PH","family":"Bokkers","sequence":"first","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochem P","family":"Bremmer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart NM","family":"van Berckel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A","family":"Lammertsma","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josien PW","family":"Pluim","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Boellaard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina JM","family":"Klijn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"key":"bibr1-jcbfm.2009.204","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199611000-00019"},{"key":"bibr2-jcbfm.2009.204","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.6.828"},{"key":"bibr3-jcbfm.2009.204","first-page":"783","volume":"43","author":"Barth M","year":"1997","journal-title":"Cell Mol Biol 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