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In this study, we used laser speckle contrast imaging to map dynamic changes in collateral blood flow after middle cerebral artery occlusion in rats. We identified extensive anastomatic connections between the anterior and middle cerebral arteries that develop after vessel occlusion and persist for 24 hours. Augmenting blood flow through these persistent yet dynamic anastomatic connections may be an important but relatively unexplored avenue in stroke therapy.<\/jats:p>","DOI":"10.1038\/jcbfm.2010.73","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T04:03:29Z","timestamp":1275451409000},"page":"1432-1436","source":"Crossref","is-referenced-by-count":120,"title":["Laser Speckle Contrast Imaging of Collateral Blood Flow during Acute Ischemic Stroke"],"prefix":"10.1177","volume":"30","author":[{"given":"Glenn A","family":"Armitage","sequence":"first","affiliation":[{"name":"Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G","family":"Todd","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Shuaib","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R","family":"Winship","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6,2]]},"reference":[{"key":"bibr1-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000122745.72175.D5"},{"key":"bibr2-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.132100"},{"key":"bibr3-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.25.002088"},{"key":"bibr4-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200103000-00002"},{"key":"bibr5-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707594"},{"key":"bibr6-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-006-9008-1"},{"key":"bibr7-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3724-08.2008"},{"key":"bibr8-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"bibr9-jcbfm.2010.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.08.012"},{"key":"#cr-split#-bibr10-jcbfm.2010.73.1","doi-asserted-by":"crossref","unstructured":"Noor R, Wang CX, Todd K, Elliott C, Wahr J, Shuaib A (2009) Partial intra-aortic occlusion improves perfusion deficits and infarct size following focal cerebral ischemia. 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