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Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.<\/jats:p>","DOI":"10.1038\/jcbfm.2011.123","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T04:07:16Z","timestamp":1316578036000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain"],"prefix":"10.1177","volume":"32","author":[{"given":"Benjamin H","family":"Brinkmann","sequence":"first","affiliation":[{"name":"Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"3D Medical Imaging, LLC, Byron, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Stead","sequence":"additional","affiliation":[{"name":"Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noojan","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology, The Royal Melbourne Hospital, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence J","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neurology, The Royal Melbourne Hospital, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson L","family":"So","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hal","family":"Blumenfeld","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P","family":"Mullan","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A","family":"Worrell","sequence":"additional","affiliation":[{"name":"Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"707","article-title":"Evaluation of methods to detect interhemispheric asymmetry on cerebral perfusion SPECT: application to epilepsy","volume":"46","author":"Aubert-Broche B","year":"2005","unstructured":"Aubert-Broche B, Jannin P, Biraben A, Bernard AM, Haegelen C, Le Jeune FP, Gibaud B (2005) Evaluation of methods to detect interhemispheric asymmetry on cerebral perfusion SPECT: application to epilepsy. 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