{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:30:11Z","timestamp":1787002211120,"version":"build-2736575974"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T00:00:00Z","timestamp":1316563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>While communicating hydrocephalus (CH) is often characterized by increased pulsatile flow of cerebrospinal fluid (CSF) in the cerebral aqueduct, a clear-cut explanation for this phenomenon is lacking. Increased pulsatility of the entire cerebral vasculature including the cortical capillaries has been suggested as a causative mechanism. To test this theory, we used two-photon microscopy to measure flow pulsatility in neocortical capillaries 40 to 500\u2009\u03bcm below the pial surface in adult rats with CH at 5 to 7 days (acute, n=8) and 3 to 5 weeks (chronic, n=5) after induction compared with intact controls ( n=9). Averaging over all cortical depths, no increase in capillary pulsatility occurred in acute (pulsatility index (PI): 0.15\u00b10.06) or chronic (0.14\u00b10.05) CH animals compared with controls (0.18\u00b10.07; P=0.07). More specifically, PI increased significantly with cortical depth in controls ( r=0.35, P&lt;0.001), but no such increase occurred in acute ( r=0.06, P=0.3) or chronic ( r=0.05, P=0.5) CH. Pulsatile CSF aqueductal flow, in contrast, was elevated 10- to 500-fold compared with controls. We conclude that even in the presence of markedly elevated pulsatile CSF flow in the aqueduct, there is no concurrent increase in microvascular pulsatile flow.<\/jats:p>","DOI":"10.1038\/jcbfm.2011.130","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T04:07:16Z","timestamp":1316578036000},"page":"318-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Neocortical Capillary Flow Pulsatility is Not Elevated in Experimental Communicating Hydrocephalus"],"prefix":"10.1177","volume":"32","author":[{"given":"Shams","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James P","family":"McAllister","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurological Surgery, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Wagshul","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Biophysics, Gruss MRRC, Albert Einstein College of Medicine, Bronx, New York, USA"},{"name":"Department of Radiology, Stony Brook University, Stony Brook, New York, 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