{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:29:39Z","timestamp":1789972179355,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T00:00:00Z","timestamp":1322611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen\/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals ( P &lt; 0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights ( r &gt; 0.88; P &lt; 0.0001) and subject scores ( r &gt; 0.74; P &lt; 0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings ( r &gt; 0.71; P &lt; 0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2011.166","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T04:07:48Z","timestamp":1322626068000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Abnormal Metabolic Brain Networks in a Nonhuman Primate Model of Parkinsonism"],"prefix":"10.1177","volume":"32","author":[{"given":"Yilong","family":"Ma","sequence":"first","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe G","family":"Spetsieris","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Sossi","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris J","family":"Doudet","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of British Columbia, Vancouver, British Columbia, 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