{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:01:36Z","timestamp":1792738896882,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    Assessment of serotonin release in the living brain with positron emission tomography (PET) may have been hampered by the lack of suitable radioligands. We previously reported that fenfluramine caused a dose-dependent reduction in specific binding in monkeys using a classical displacement paradigm with bolus administration of [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369. The aim of this study was to confirm our previous findings using an equilibrium approach in monkey. A total of 24 PET measurements were conducted using a bolus infusion protocol of [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 in three cynomolgus monkeys. Initial PET measurements were performed to assess suitable K\n                    <jats:sub>bol<\/jats:sub>\n                    values. The fenfluramine effect on [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 binding was evaluated in a displacement and pretreatment paradigm. The effect of fenfluramine on [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 binding potential ( BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) was dose-dependent in the displacement paradigm and confirmed in the pretreatment paradigm. After pretreatment administration of fenfluramine (5.0 mg\/kg), the mean BP\n                    <jats:sub>ND<\/jats:sub>\n                    of the occipital cortex decreased by 39%, from 1.38 \u00b1 0.04 to 0.84 \u00b1 0.09. This study confirms that the new 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptor radioligand [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 is sensitive to fenfluramine-induced changes in endogenous serotonin levels in vivo. The more advanced methodology is suitable for exploring the sensitivity limit to serotonin release as measured using [\n                    <jats:sup>11<\/jats:sup>\n                    C]AZ10419369 and PET.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2011.172","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T04:11:13Z","timestamp":1323835873000},"page":"685-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Confirmation of Fenfluramine Effect on 5-HT\n                    <sub>1B<\/sub>\n                    Receptor Binding of [\n                    <sup>11<\/sup>\n                    C]AZ10419369 using an Equilibrium Approach"],"prefix":"10.1177","volume":"32","author":[{"given":"Sjoerd J","family":"Finnema","sequence":"first","affiliation":[{"name":"Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Varrone","sequence":"additional","affiliation":[{"name":"Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung-Jeng","family":"Hwang","sequence":"additional","affiliation":[{"name":"Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Halldin","sequence":"additional","affiliation":[{"name":"Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Farde","sequence":"additional","affiliation":[{"name":"Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"},{"name":"AstraZeneca, R&D, S\u00f6dert\u00e4lje, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"bibr1-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.08.006"},{"key":"bibr2-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"bibr3-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2569"},{"key":"bibr4-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.6"},{"key":"bibr5-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199704000-00009"},{"key":"bibr6-jcbfm.2011.172","volume-title":"Guide for the Care and Use of Laboratory Animals.","author":"Clark JD","year":"1996"},{"key":"bibr7-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20942"},{"key":"bibr8-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/BF00633189"},{"key":"bibr9-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20780"},{"key":"bibr10-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6663(86)80050-2"},{"key":"bibr11-jcbfm.2011.172","first-page":"31","volume":"288","author":"G\u00f6thert M","year":"1987","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"bibr12-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.1069"},{"key":"bibr13-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493"},{"key":"bibr14-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199809000-00003"},{"key":"bibr15-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245691"},{"key":"bibr16-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/30498"},{"key":"bibr17-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200003000-00001"},{"key":"bibr18-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9235"},{"key":"bibr19-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.101"},{"key":"bibr20-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.150722"},{"key":"bibr21-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/BF00569364"},{"key":"bibr22-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169550"},{"key":"bibr23-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.83"},{"key":"bibr24-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.104"},{"key":"bibr25-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.063"},{"key":"bibr26-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20946"},{"key":"bibr27-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(93)90109-S"},{"key":"bibr28-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900067"},{"key":"bibr29-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900163"},{"key":"bibr30-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00256-5"},{"key":"bibr31-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.190"},{"key":"bibr32-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10134"},{"key":"bibr33-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20209"},{"key":"bibr34-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02823-2"},{"key":"bibr35-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20035"},{"key":"bibr36-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.55"},{"key":"bibr37-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2165-z"},{"key":"bibr38-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1156-3"},{"key":"bibr39-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890160402"},{"key":"bibr40-jcbfm.2011.172","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00696.x"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2011.172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2011.172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2011.172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:10:08Z","timestamp":1777493408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2011.172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1038\/jcbfm.2011.172"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2011.172","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}