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In addition to resident neural stem cell activation in the brain by neurotrophic factors, bone marrow stem cells (BMSCs) can be mobilized by granulocyte-colony stimulating factor for homing into the brain for both neurorepair and neuroregeneration in acute stroke and neurodegenerative diseases in both basic science and clinical settings. Exogenous stem cell transplantation is also emerging into a clinical scene from bench side experiments. Early clinical trials of intravenous transplantation of autologous BMSCs are showing safe and effective results in stroke patients. Further basic sciences of stem cell therapy on a neurovascular unit and neuroregeneration, and further clinical advancements on scaffold technology for supporting stem cells and stem cell tracking technology such as magnetic resonance imaging, single photon emission tomography or optical imaging with near-infrared could allow stem cell therapy to be applied in daily clinical applications in the near future.<\/jats:p>","DOI":"10.1038\/jcbfm.2011.187","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T04:10:53Z","timestamp":1326859853000},"page":"1317-1331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":115,"title":["Stem Cell Therapy for Cerebral Ischemia: From Basic Science to Clinical Applications"],"prefix":"10.1177","volume":"32","author":[{"given":"Koji","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Neurology, Okayama University Medical School, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Okayama University Medical School, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tokai University School of Medicine, Isehara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kinouchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yamanashi University Medical School, Kofu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokomaha, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"bibr1-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200010000-00001"},{"key":"bibr2-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.8.1478"},{"key":"bibr3-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63269-0"},{"key":"bibr4-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90018-O"},{"key":"bibr5-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002"},{"key":"bibr6-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"bibr7-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20501"},{"key":"bibr8-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000247888.25985.62"},{"key":"bibr9-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.3.3.249"},{"key":"bibr10-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.198"},{"key":"bibr11-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl261"},{"key":"bibr12-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115107"},{"key":"bibr13-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0319"},{"key":"bibr14-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1038\/nature10284"},{"key":"bibr15-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702072"},{"key":"bibr16-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.11.015"},{"key":"bibr17-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0452"},{"key":"bibr18-jcbfm.2011.187","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000341905.57162.1D"},{"key":"bibr19-jcbfm.2011.187","doi-asserted-by":"crossref","unstructured":"Chiba Y, Kuroda S, Osanai T, Shichinohe H, Houkin K, Iwasaki Y (2011) Impact of ageing on biological features of bone marrow stromal cells (BMSC) in cell transplantation therapy for central nervous system disorders\u2014Functional enhancement by granulocyte-colony stimulating factor (G-CSF). 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