{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:22:02Z","timestamp":1789748522880,"version":"4.0.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    Although D2\/3 agonists have been used as a first-line medication for idiopathic restless legs syndrome (iRLS), findings on D2\/3 receptors have been inconsistent. Here, we aimed to clarify the contribution of D2\/3 receptor function to the clinical symptoms of iRLS by comparing the binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride with clinical improvements after D2\/3 stimulation by pramipexole. Eight drug-na\u00efve, iRLS patients and eight age-matched healthy subjects were scanned with positron emission tomography (PET). After PET scans, all patients received pramipexole (0.125 mg) orally for 2 weeks. Patients were evaluated every day with several standardized clinical tests. The BP\n                    <jats:sub>ND<\/jats:sub>\n                    values were compared using regions of interest and voxel-based methods. Results showed that the mean magnitude of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride BP\n                    <jats:sub>ND<\/jats:sub>\n                    in the mesolimbic dopamine region (nucleus accumbens (NA) and caudate) was significantly lower in the iRLS group. No significant differences between groups were observed in the putamen. The NA [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride BP\n                    <jats:sub>ND<\/jats:sub>\n                    levels correlated negatively with clinical severity scores and positively with the degree of posttreatment improvement in iRLS. The present results suggest that alterations in mesolimbic D2\/3 receptor function reflect the pathophysiology of iRLS, and the baseline availability of D2\/3 receptors may predict the clinical outcome after D2\/3 agonist treatment.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2011.201","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T04:07:06Z","timestamp":1326254826000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["<i>In vivo<\/i>\n                    Mesolimbic D2\/3 Receptor Binding Predicts Posttherapeutic Clinical Responses in Restless Legs Syndrome: A Positron Emission Tomography Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Yumi","family":"Oboshi","sequence":"first","affiliation":[{"name":"Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuomi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nagoya Daini Red Cross Hospital, Nagoya, 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