{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:44:11Z","timestamp":1790855051019,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Magnetic resonance imaging (MRI) of the brain could be a powerful tool for discovering early biomarkers in clinically presymptomatic carriers of the Huntington's disease gene mutation (preHD). The aim of this study was to investigate the sensitivity of resting-state perfusion MRI in preHD and to identify neural changes, which could serve as biomarkers for future clinical trials. Differences in regional cerebral blood flow (rCBF) in 18 preHD and 18 controls were assessed with a novel MRI method based on perfusion images obtained with continuous arterial spin labeling. High-resolution structural data were collected to test for changes of brain volume. Compared with controls, preHD individuals showed decreased rCBF in medial and lateral prefrontal regions and increased rCBF in the precuneus. PreHD near to symptom onset additionally showed decreased rCBF in the putamen and increased rCBF in the hippocampus. Network analyses revealed an abnormal lateral prefrontal pattern in preHD far and near to motor onset. These data suggest early changes of frontostriatal baseline perfusion in preHD independent of substantial reductions of gray matter volume. This study also shows the feasibility of detecting neural changes in preHD with a robust MRI technique that would be suitable for longitudinal multisite application.<\/jats:p>","DOI":"10.1038\/jcbfm.2011.60","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T04:27:50Z","timestamp":1305088070000},"page":"1908-1918","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Robert C","family":"Wolf","sequence":"first","affiliation":[{"name":"Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany"},{"name":"Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gr\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Brain Center for Motor and Social Cognition, Italian Institute of Technology, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Vasic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine D","family":"Wolf","sequence":"additional","affiliation":[{"name":"Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A","family":"Thomann","sequence":"additional","affiliation":[{"name":"Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Saft","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Josef-Hospital, University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Bernhard","family":"Landwehrmeyer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Orth","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"bibr1-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1162\/089892900562174"},{"key":"bibr2-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"bibr3-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.10.028"},{"key":"bibr4-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2008.20.4.466"},{"issue":"2","key":"bibr5-jcbfm.2011.60","doi-asserted-by":"crossref","DOI":"10.1006\/nimg.2001.0845","volume":"16","author":"Brett M","year":"2002","journal-title":"Neuroimage"},{"key":"bibr6-jcbfm.2011.60","first-page":"215","volume":"47","author":"Ciarmiello A","year":"2006","journal-title":"J Nucl Med"},{"key":"bibr7-jcbfm.2011.60","first-page":"401","volume":"5","author":"Correa N","year":"2005","journal-title":"Proc IEEE Int Conf Acoustics, Speech, Signal Processing"},{"key":"bibr8-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02550-7"},{"key":"bibr9-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00038-X"},{"key":"bibr10-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1007\/s11068-004-0514-8"},{"key":"bibr11-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.06.003"},{"key":"bibr12-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm217"},{"key":"bibr13-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20684"},{"key":"bibr14-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10416"},{"key":"bibr15-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999"},{"key":"bibr16-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1667"},{"key":"bibr17-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.11.1018"},{"key":"bibr18-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.190702"},{"key":"bibr19-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"bibr20-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp081"},{"key":"bibr21-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.045"},{"key":"bibr22-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"bibr23-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20359"},{"key":"bibr24-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.073"},{"key":"bibr25-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"bibr26-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07733.2001"},{"key":"bibr27-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.015"},{"key":"bibr28-jcbfm.2011.60","first-page":"1715","volume":"25","author":"Paulsen JS","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"bibr29-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.068"},{"key":"bibr30-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh608"},{"key":"bibr31-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1223409"},{"key":"bibr32-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00060-0"},{"key":"bibr33-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20096"},{"key":"bibr34-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"bibr35-jcbfm.2011.60","volume-title":"Co-Planar Stereotaxic Atlas of the Human Brain","author":"Talairach J","year":"1988"},{"key":"bibr36-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.009"},{"key":"bibr37-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"bibr38-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00255-6"},{"key":"bibr39-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2351031663"},{"key":"bibr40-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.017"},{"key":"bibr41-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02253.x"},{"key":"bibr42-jcbfm.2011.60","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm210"},{"key":"bibr43-jcbfm.2011.60","first-page":"758","volume":"13","author":"Zimbelman JL","year":"2007","journal-title":"J Int NeuropsycholSoc"},{"key":"bibr44-jcbfm.2011.60","volume-title":"Testbatterie zur Aufmerksamkeitspr\u00fcfung (TAP)","author":"Zimmermann P","year":"1994"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2011.60","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2011.60","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2011.60","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:09:45Z","timestamp":1777493385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2011.60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,11]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1038\/jcbfm.2011.60"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2011.60","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,11]]}}}