{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:37:05Z","timestamp":1777793825074,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Cerebral vasospasm after aneurysmal subarachnoid hemorrhage is a potentially severe sequel. The induction of hypertension, hypervolemia, and hemodilution is advocated for vasospasm, but it is unclear whether hemodilution confers any benefit. A finite element model of oxygen transport in the proximal middle cerebral artery (MCA) was used to evaluate the complex relationship among hematocrit, viscosity, oxygen content, and blood flow in the setting of vasospasm. A single-phase non-Newtonian finite element model based on three-dimensional incompressible Navier\u2013Stokes equations was constructed of the M1 segment. The model was solved at vessel stenoses ranging from 0% to 90% and hematocrit from 0.2 to 0.6. A small area of poststenotic recirculation was seen with mild (30%) stenosis. Poststenotic eddy formation was noted with more severe (60% to 90%) stenosis. Volumetric flow was inversely related to hematocrit at mild stenosis (0% to 30%). With near-complete stenosis (90%), a paradoxical increase in flow was seen with increasing hematocrit. Oxygen transport across the segment was related to hematocrit at all levels of stenosis with increasing oxygen transport despite a reduction in blood flow, suggesting that with clinically significant vasospasm in the MCA, hemodilution does not improve oxygen transport, but to the contrary, that ischemia may be worsened.<\/jats:p>","DOI":"10.1038\/jcbfm.2011.83","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T03:57:13Z","timestamp":1306900633000},"page":"2209-2217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Computational Simulation of the Effect of Hemodilution on Oxygen Transport in Middle Cerebral Artery Vasospasm"],"prefix":"10.1177","volume":"31","author":[{"given":"Prashant","family":"Chittiboina","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Guthikonda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wollblad","sequence":"additional","affiliation":[{"name":"COMSOL AB, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"},{"name":"Department of Medicine and Emergency Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"},{"name":"Department of Biomedical Engineering, Louisiana Tech University, Ruston, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"bibr1-jcbfm.2011.83","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.2.365"},{"key":"bibr2-jcbfm.2011.83","doi-asserted-by":"publisher","DOI":"10.1002\/fld.1484"},{"key":"bibr3-jcbfm.2011.83","doi-asserted-by":"publisher","DOI":"10.1016\/0037-198X(71)90016-2"},{"key":"bibr4-jcbfm.2011.83","unstructured":"Bird RB, Armstrong RC, Hassager O (1987) Dynamics of Polymeric Liquids. 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