{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:26Z","timestamp":1792670846173,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T00:00:00Z","timestamp":1342569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Delivery of therapeutic or diagnostic agents to the brain is majorly hindered by the blood\u2013brain barrier (BBB). Recently, many studies have demonstrated local and transient disruption of the BBB using low power ultrasound sonication combined with intravascular microbubbles. However, BBB opening and closure mechanisms are poorly understood, especially the maximum gap that may be safely generated between endothelial cells and the duration of opening of the BBB. Here, we studied BBB opening and closure under magnetic resonance (MR) guidance in a rat model. First, MR contrast agents (CA) of different hydrodynamic diameters (1 to 65\u2009nm) were employed to estimate the largest molecular size permissible across the cerebral tissues. Second, to estimate the duration of the BBB opening, the CA were injected at various times post-BBB disruption (12 minutes to 24 hours). A T\n                    <jats:sub>1<\/jats:sub>\n                    mapping strategy was developed to assess CA concentration at the ultrasound (US) focal point. Based on our experimental data and BBB closure modeling, a calibration curve was obtained to compute the half closure time as a function of CA hydrodynamic diameter. These findings and the model provide an invaluable basis for optimal design and delivery of nanoparticles to the brain.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2012.100","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T04:00:43Z","timestamp":1342584043000},"page":"1948-1958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":192,"title":["Dynamic Study of Blood\u2013Brain Barrier Closure after its Disruption using Ultrasound: A Quantitative Analysis"],"prefix":"10.1177","volume":"32","author":[{"given":"Benjamin","family":"Marty","sequence":"first","affiliation":[{"name":"NeuroSpin, I2BM, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Larrat","sequence":"additional","affiliation":[{"name":"NeuroSpin, I2BM, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Gif-sur-Yvette, France"},{"name":"Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Van Landeghem","sequence":"additional","affiliation":[{"name":"PPMD, ESPCI ParisTech, CNRS UMR 7615, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Robic","sequence":"additional","affiliation":[{"name":"Guerbet Research Division, Roissy-Charles de Gaulle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Robert","sequence":"additional","affiliation":[{"name":"Guerbet Research Division, Roissy-Charles de Gaulle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Port","sequence":"additional","affiliation":[{"name":"Guerbet Research Division, Roissy-Charles de Gaulle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Le Bihan","sequence":"additional","affiliation":[{"name":"NeuroSpin, I2BM, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pernot","sequence":"additional","affiliation":[{"name":"Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Tanter","sequence":"additional","affiliation":[{"name":"Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Lethimonnier","sequence":"additional","affiliation":[{"name":"NeuroSpin, I2BM, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"M\u00e9riaux","sequence":"additional","affiliation":[{"name":"NeuroSpin, I2BM, Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,18]]},"reference":[{"key":"bibr1-jcbfm.2012.100","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq054"},{"key":"bibr2-jcbfm.2012.100","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.155"},{"key":"bibr3-jcbfm.2012.100","doi-asserted-by":"crossref","unstructured":"Choi JJ, Small SA, Konofagou EE (2006) Optimization of blood-brain barrier opening in mice using focused ultrasound. 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