{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:29:25Z","timestamp":1777793365520,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    We have developed a feedback-controlled bolus plus infusion (FC-B\/I) method for monitoring the interaction between positron emission tomography (PET) ligands and their specific target molecules with PET. The usefulness of the FC-B\/I method was evaluated by the direct interaction between [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride, a dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor (D\n                    <jats:sub>2<\/jats:sub>\n                    R) ligand, and cold raclopride (10 and 100 \u03bcg\/kg) in the brains of conscious monkeys. The present results demonstrated that the FC-B\/I method could achieve the equilibrium state of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride in the striatum of monkey brain, and also that the cold raclopride-induced reduction of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride binding to D\n                    <jats:sub>2<\/jats:sub>\n                    R was observed in a dose-dependent manner. Good correlations of distribution volume ratio of the striatum to cerebellum between the conventional bolus plus infusion (B\/I) method and the FC-B\/I method as well as between the conventional bolus injection method and the FC-B\/I method were observed. These results indicated that the system could be a useful tool for the evaluation of interaction between drug candidates and their target molecules like enzymes, receptors, and transporters by using of their specific PET ligands.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2012.134","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T04:05:33Z","timestamp":1347422733000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Feedback-Controlled Bolus plus Infusion (FC-B\/I) Method for Quantitative Drug Assessment in Living Brain with PET"],"prefix":"10.1177","volume":"33","author":[{"given":"Hiroyuki","family":"Ohba","sequence":"first","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Harada","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,12]]},"reference":[{"key":"bibr1-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.98"},{"key":"bibr2-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199704000-00009"},{"key":"bibr3-jcbfm.2012.134","first-page":"522","volume":"41","author":"Watabe H","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr4-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1126\/science.2867601"},{"key":"bibr5-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00821.1995"},{"key":"bibr6-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200003000-00001"},{"key":"bibr7-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-07067.2000"},{"key":"bibr8-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00138-4"},{"key":"bibr9-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199709000-00002"},{"key":"bibr10-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199811000-00006"},{"key":"bibr11-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.6"},{"key":"bibr12-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ics.2003.12.077"},{"key":"bibr13-jcbfm.2012.134","doi-asserted-by":"crossref","unstructured":"Harada N, Ohba H, Kakiuchi T, Tsukada H. Application of feedback-controlled bolus plus infusion (FC-B\/I) method for quantitative PET imaging of dopamine transporters with [18F]\u03b2-CFT-FE in conscious monkey brain. Synapse 2012, (In Press).","DOI":"10.1002\/syn.21614"},{"key":"bibr14-jcbfm.2012.134","first-page":"59","volume-title":"PID Control","author":"\u00c5str\u00f6m KJ","year":"1995","edition":"2"},{"key":"bibr15-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580240808"},{"key":"bibr16-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1109\/23.597001"},{"key":"bibr17-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000038000.34930.4E"},{"key":"bibr18-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600584"},{"key":"bibr19-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.132"},{"key":"bibr20-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493"},{"key":"bibr21-jcbfm.2012.134","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20059"},{"key":"bibr22-jcbfm.2012.134","first-page":"2083","volume":"41","author":"Slifstein M","year":"2000","journal-title":"J Nucl Med"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2012.134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:10:27Z","timestamp":1777493427000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2012.134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1038\/jcbfm.2012.134"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2012.134","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]}}}