{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:11:17Z","timestamp":1791573077694,"version":"4.3.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    Cerebral metabolic rate of oxygen consumption ( CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ), cerebral blood flow ( CBF), and oxygen extraction fraction ( OEF) are important indices of healthy aging of the brain. Although a frequent topic of study, changes of CBF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    during normal aging are still controversial, as some authors find decreases of both CBF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    but increased OEF, while others find no change, and yet other find divergent changes. In this reanalysis of previously published results from positron emission tomography of healthy volunteers, we determined CMRO\n                    <jats:sub>2<\/jats:sub>\n                    and CBF in 66 healthy volunteers aged 21 to 81 years. The magnitudes of CMRO\n                    <jats:sub>2<\/jats:sub>\n                    and CBF declined in large parts of the cerebral cortex, including association areas, but the primary motor and sensory areas were relatively spared. We found significant increases of OEF in frontal and parietal cortices, excluding primary motor and somatosensory regions, and in the temporal cortex. Because of the inverse relation between OEF and capillary oxygen tension, increased OEF can compromise oxygen delivery to neurons, with possible perturbation of energy turnover. The results establish a possible mechanism of progression from healthy to unhealthy brain aging, as the regions most affected by age are the areas that are most vulnerable to neurodegeneration.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2012.18","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T08:01:19Z","timestamp":1330502479000},"page":"1177-1187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":169,"title":["Brain Energy Metabolism and Blood Flow Differences in Healthy Aging"],"prefix":"10.1177","volume":"32","author":[{"given":"Joel","family":"Aanerud","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Borghammer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Mallar","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Hospital, Toronto, Ontario, Canada"},{"name":"Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Vang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders B","family":"Rodell","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristjana Y","family":"J\u00f3nsdottir","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Center of Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ashkanian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Center of Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manouchehr S","family":"Vafaee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Memory Disorders Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Gjedde","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Center of Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark"},{"name":"Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark"},{"name":"Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark"},{"name":"McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"bibr1-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.076"},{"key":"bibr2-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.89"},{"key":"bibr3-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.021"},{"key":"bibr4-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.042"},{"key":"bibr5-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.057"},{"key":"bibr6-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S305"},{"key":"bibr7-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/21.5.316"},{"key":"bibr8-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199701000-00009"},{"key":"bibr9-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1142\/S0218001497000597"},{"key":"bibr10-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030304"},{"key":"bibr11-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(95)00021-T"},{"key":"bibr12-jcbfm.2012.18","first-page":"23","volume-title":"Cerebrovascular Disease,","author":"Gjedde A","year":"1997"},{"key":"bibr13-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7756-4_32"},{"key":"bibr14-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600113"},{"key":"bibr15-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-010-9179-9"},{"key":"bibr16-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200201000-00001"},{"key":"bibr17-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90015-K"},{"key":"bibr18-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.13"},{"key":"bibr19-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200008000-00011"},{"key":"bibr20-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1159\/000213174"},{"key":"bibr21-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.057"},{"key":"bibr22-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(56)90146-1"},{"key":"bibr23-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1945.143.1.53"},{"key":"bibr24-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101994"},{"key":"bibr25-jcbfm.2012.18","volume-title":"Solving Least Squares Problems.","author":"Lawson G","year":"1974"},{"key":"bibr26-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.1.27"},{"key":"bibr27-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1159\/000115248"},{"key":"bibr28-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq224"},{"key":"bibr29-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530340029014"},{"key":"bibr30-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.121"},{"key":"bibr31-jcbfm.2012.18","first-page":"1842","volume":"41","author":"Meltzer CC","year":"2000","journal-title":"J Nucl Med"},{"key":"bibr32-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1080\/03014467700007142"},{"key":"bibr33-jcbfm.2012.18","first-page":"177","volume":"25","author":"Mintun MA","year":"1984","journal-title":"J Nucl Med"},{"key":"bibr34-jcbfm.2012.18","unstructured":"M\u00f8ller A, Roepstorff A, Cumming P, Pedersen GF, Bailey C, Gjedde A (2006) Cerebrometabolic Effects of Non-Ionizing Radiation from Cell Phones. International Conference On Brain Energy Metabolism, poster session: Lausanne."},{"key":"bibr35-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000041048.33908.18"},{"key":"bibr36-jcbfm.2012.18","first-page":"53","volume":"1147","author":"Nicholls DG","year":"2008","journal-title":"Mitochondria and Oxidative Stress in Neurodegenerative Disorders"},{"key":"bibr37-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00002"},{"key":"bibr38-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.28"},{"key":"bibr39-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K"},{"key":"bibr40-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.4.635"},{"key":"bibr41-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.1.46"},{"key":"bibr42-jcbfm.2012.18","first-page":"790","volume":"24","author":"Raichle ME","year":"1983","journal-title":"J Nucl Med"},{"key":"bibr43-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.536839"},{"key":"bibr44-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1007\/s0054020060297"},{"key":"bibr45-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1007\/s0054020060051"},{"key":"bibr46-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1992.11740031"},{"key":"bibr47-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200004000-00012"},{"key":"bibr48-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.10.003"},{"key":"bibr49-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0933"},{"key":"bibr50-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O"},{"key":"bibr51-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.015"},{"key":"bibr52-jcbfm.2012.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1220"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2012.18","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:10:18Z","timestamp":1777493418000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2012.18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1038\/jcbfm.2012.18"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2012.18","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}