{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:26:34Z","timestamp":1790634394035,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Positron emission tomography ( PET) with\n                    <jats:sup>15<\/jats:sup>\n                    O tracers provides essential information in patients with cerebral vascular disorders, such as cerebral blood flow ( CBF), oxygen extraction fraction ( OEF), and metabolic rate of oxygen ( CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ). However, most of techniques require an additional C\n                    <jats:sup>15<\/jats:sup>\n                    O scan for compensating cerebral blood volume ( CBV). We aimed to establish a technique to calculate all functional images only from a single dynamic PET scan, without losing accuracy or statistical certainties. The technique was an extension of previous dual-tracer autoradiography (DARG) approach, but based on the basis function method (DBFM), thus estimating all functional parametric images from a single session of dynamic scan acquired during the sequential administration of H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O and\n                    <jats:sup>15<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Validity was tested on six monkeys by comparing global OEF by PET with those by arteriovenous blood sampling, and tested feasibility on young healthy subjects. The mean DBFM-derived global OEF was 0.57 \u00b1 0.06 in monkeys, in an agreement with that by the arteriovenous method (0.54 \u00b1 0.06). Image quality was similar and no significant differences were seen from DARG; 3.57% \u00b1 6.44% and 3.84% \u00b1 3.42% for CBF, and \u22122.79% \u00b1 11.2% and \u22126.68% \u00b1 10.5% for CMRO\n                    <jats:sub>2<\/jats:sub>\n                    . A simulation study demonstrated similar error propagation between DBFM and DARG. The DBFM method enables accurate assessment of CBF and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    without additional CBV scan within significantly shortened examination period, in clinical settings.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2012.188","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T04:02:08Z","timestamp":1355284928000},"page":"440-448","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["Rapid Quantitative\n                    <i>CBF<\/i>\n                    and\n                    <i>CMRO<\/i>\n                    <sub>2<\/sub>\n                    Measurements from a Single\n                    <i>PET<\/i>\n                    Scan with Sequential Administration of Dual\n                    <sup>15<\/sup>\n                    O-Labeled Tracers"],"prefix":"10.1177","volume":"33","author":[{"given":"Nobuyuki","family":"Kudomi","sequence":"first","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"},{"name":"Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Koshino","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"},{"name":"Present address: Kobe MI R&D Center, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"},{"name":"Present address: Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Iihara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Cerebral and Cardiovascular Center, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"bibr1-jcbfm.2012.188","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1980.tb03046.x"},{"key":"bibr2-jcbfm.2012.188","first-page":"177","volume":"25","author":"Mintun MA","year":"1984","journal-title":"J Nucl Med"},{"key":"bibr3-jcbfm.2012.188","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198206000-00022"},{"key":"bibr4-jcbfm.2012.188","first-page":"48","volume":"19","author":"Subramanyam R","year":"1978","journal-title":"J Nucl Med"},{"key":"bibr5-jcbfm.2012.188","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111164398"},{"key":"bibr6-jcbfm.2012.188","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165003"},{"key":"bibr7-jcbfm.2012.188","first-page":"765","volume":"45","author":"Hattori N","year":"2004","journal-title":"J Nucl 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