{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:34Z","timestamp":1791288694626,"version":"4.3.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Optical imaging of changes in total hemoglobin concentration ( HbT), cerebral blood volume ( CBV), and hemoglobin oxygen saturation ( SO\n                    <jats:sub>2<\/jats:sub>\n                    ) provides a means to investigate brain hemodynamic regulation. However, high-resolution transcranial imaging remains challenging. In this study, we applied a novel functional photoacoustic microscopy technique to probe the responses of single cortical vessels to left forepaw electrical stimulation in mice with intact skulls. Functional changes in HbT, CBV, and SO\n                    <jats:sub>2<\/jats:sub>\n                    in the superior sagittal sinus and different-sized arterioles from the anterior cerebral artery system were bilaterally imaged with unambiguous 36 \u00d7 65- \u03bcm\n                    <jats:sup>2<\/jats:sup>\n                    spatial resolution. In addition, an early decrease of SO\n                    <jats:sub>2<\/jats:sub>\n                    in single blood vessels during activation (i.e., \u2018the initial dip\u2019) was observed. Our results indicate that the initial dip occurred specifically in small arterioles of activated regions but not in large veins. This technique complements other existing imaging approaches for the investigation of the hemodynamic responses in single cerebral blood vessels.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2012.42","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T04:22:51Z","timestamp":1333513371000},"page":"938-951","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Transcranial Imaging of Functional Cerebral Hemodynamic Changes in Single Blood Vessels using\n                    <i>in vivo<\/i>\n                    Photoacoustic Microscopy"],"prefix":"10.1177","volume":"32","author":[{"given":"Lun-De","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering, National Chiao Tung University, Hsinchu, Taiwan"},{"name":"Brain Research Center, National Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Teng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Chiao Tung University, Hsinchu, Taiwan"},{"name":"Brain Research Center, National Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Yu I","family":"Shih","sequence":"additional","affiliation":[{"name":"Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Q","family":"Duong","sequence":"additional","affiliation":[{"name":"Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yi","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robby","family":"Wu","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siny","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh-Yeong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"bibr1-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.2011899"},{"key":"bibr2-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.015670"},{"key":"bibr3-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0326-07.2007"},{"key":"bibr4-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.083"},{"key":"bibr5-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.052"},{"key":"bibr6-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1834"},{"key":"bibr7-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2009.0090"},{"key":"bibr8-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200008)44:2<231::AID-MRM10>3.0.CO;2-T"},{"key":"bibr9-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1067"},{"key":"bibr10-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1117\/1.2789693"},{"key":"bibr11-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.032"},{"key":"bibr12-jcbfm.2012.42","first-page":"12","volume":"2","author":"Hu S","year":"2010","journal-title":"Front Neuroenerg"},{"key":"bibr13-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1038\/72109"},{"key":"bibr14-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21981"},{"key":"bibr15-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1117\/1.3302807"},{"key":"bibr16-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1117\/1.2717531"},{"key":"bibr17-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.07.013"},{"key":"bibr18-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.001824"},{"key":"bibr19-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.065"},{"key":"bibr20-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0709"},{"key":"bibr21-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5261.551"},{"key":"bibr22-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390415"},{"key":"bibr23-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1364\/OL.30.000625"},{"key":"bibr24-jcbfm.2012.42","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2001","edition":"2"},{"key":"bibr25-jcbfm.2012.42","volume-title":"The Mouse Brain in Stereotaxic Coordinates.","author":"Paxinos G","year":"2003"},{"key":"bibr26-jcbfm.2012.42","volume-title":"The Rat Nervous System","author":"Paxinos G","year":"2004","edition":"3"},{"key":"bibr27-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.007285"},{"key":"bibr28-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1159\/000114443"},{"key":"bibr29-jcbfm.2012.42","first-page":"541","volume":"29","author":"Roston S","year":"1967","journal-title":"B Math Biol"},{"key":"bibr30-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5918-2-6"},{"key":"bibr31-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3447-08.2009"},{"key":"bibr32-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/48\/10\/311"},{"key":"bibr33-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1117\/1.3095799"},{"key":"bibr34-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914194107"},{"key":"bibr35-jcbfm.2012.42","first-page":"1035","volume":"7","author":"Van Hemelrijck J","year":"1993","journal-title":"Clin Anaesth"},{"key":"bibr36-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050825"},{"key":"bibr37-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4147-07.2008"},{"key":"bibr38-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.715"},{"key":"bibr39-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.222"},{"key":"bibr40-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1117\/1.3339953"},{"key":"bibr41-jcbfm.2012.42","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1220"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.42","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2012.42","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2012.42","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:10:16Z","timestamp":1777493416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2012.42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1038\/jcbfm.2012.42"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2012.42","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}