{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:29:45Z","timestamp":1777793385123,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T00:00:00Z","timestamp":1375228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>\n                    Autoregulation of cerebral perfusion is impaired in hypoxic-ischemic encephalopathy. We investigated whether cerebrovascular pressure reactivity (PRx), an element of cerebral autoregulation that is calculated as a moving correlation coefficient between averages of intracranial and mean arterial blood pressure (MABP) with values between \u22121 and +1, is impaired during and after a hypoxic-ischemic insult (HI) in newborn pigs. Associations between end-tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    , seizures, neuropathology, and PRx were investigated. The effect of hypothermia (HT) and Xenon (Xe) on PRx was studied. Pigs were randomized to Sham, and after HI to normothermia (NT), HT, Xe or xenon hypothermia (XeHT). We defined PRx &gt;0.2 as peak and negative PRx as preserved. Neuropathology scores after 72 hours of survival was grouped as \u2018severe\u2019 or \u2018mild.\u2019 Secondary PRx peak during recovery, predictive of severe neuropathology and associated with insult severity ( P = 0.05), was delayed in HT (11.5 hours) than in NT (6.5 hours) groups. Seizures were associated with impaired PRx in NT pigs ( P = 0.0002), but not in the HT\/XeHT pigs. PRx was preserved during normocapnia and impaired during hypocapnia. Xenon abolished the secondary PRx peak, increased (mean (95% confidence interval (CI)) MABP (6.5 (3.8, 9.4) mm Hg) and cerebral perfusion pressure (5.9 (2.9, 8.9) mm Hg) and preserved the PRx (regression coefficient, \u22120.098 (95% CI (\u22120.18, \u22120.01)), independent of the insult severity.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2013.123","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T04:17:40Z","timestamp":1375244260000},"page":"1752-1760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Xenon and Hypothermia on Cerebrovascular Pressure Reactivity in Newborn Global Hypoxic\u2014ischemic Pig Model"],"prefix":"10.1177","volume":"33","author":[{"given":"Elavazhagan","family":"Chakkarapani","sequence":"first","affiliation":[{"name":"Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dingley","sequence":"additional","affiliation":[{"name":"Anaesthetics, University of Swansea College of Medicine, Swansea, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Aquilina","sequence":"additional","affiliation":[{"name":"Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damjan","family":"Osredkar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Liu","sequence":"additional","affiliation":[{"name":"Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Thoresen","sequence":"additional","affiliation":[{"name":"Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK"},{"name":"Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,7,31]]},"reference":[{"key":"bibr1-jcbfm.2013.123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00695.x"},{"key":"bibr2-jcbfm.2013.123","first-page":"161","volume":"2","author":"Paulson OB","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"bibr3-jcbfm.2013.123","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2008.25.10.E2"},{"key":"bibr4-jcbfm.2013.123","first-page":"74","volume":"71","author":"Czosnyka M","year":"1998","journal-title":"Acta Neurochir 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