{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:26:34Z","timestamp":1790731594935,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    O-methyl metabolite (L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD) of\n                    <jats:sup>11<\/jats:sup>\n                    C-labeled L-3,4-dihydroxyphenylalanine (L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]DOPA) can penetrate into brain tissue through the blood\u2013brain barrier, and can complicate the estimation of dopamine synthesis capacity by positron emission tomography (PET) study with L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]DOPA. We evaluated the impact of L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD on the estimation of the dopamine synthesis capacity in a human L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]DOPA PET study. The metabolite correction with mathematical modeling of L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD kinetics in a reference region without decarboxylation and further metabolism, proposed by a previous [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDOPA PET study, were implemented to estimate radioactivity of tissue L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD in 10 normal volunteers. The component of L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD in tissue time-activity curves (TACs) in 10 regions were subtracted by the estimated radioactivity of L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD. To evaluate the influence of omitting blood sampling and metabolite correction, relative dopamine synthesis rate ( k\n                    <jats:sub>ref<\/jats:sub>\n                    ) was estimated by Gjedde\u2013Patlak analysis with reference tissue input function, as well as the net dopamine synthesis rate ( K\n                    <jats:sub>i<\/jats:sub>\n                    ) by Gjedde\u2013Patlak analysis with the arterial input function and TAC without and with metabolite correction. Overestimation of K\n                    <jats:sub>i<\/jats:sub>\n                    was observed without metabolite correction. However, the k\n                    <jats:sub>ref<\/jats:sub>\n                    and K\n                    <jats:sub>i<\/jats:sub>\n                    with metabolite correction were significantly correlated. These data suggest that the influence of L-[ \u03b2-\n                    <jats:sup>11<\/jats:sup>\n                    C]OMD is minimal for the estimation of k\n                    <jats:sub>ref<\/jats:sub>\n                    as dopamine synthesis capacity.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2013.187","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T03:54:51Z","timestamp":1383710091000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of O-Methylated Metabolite Penetrating the Blood\u2013Brain Barrier to Estimation of Dopamine Synthesis Capacity in Human L-[\n                    <i>\u03b2<\/i>\n                    -\n                    <sup>11<\/sup>\n                    C]DOPA PET"],"prefix":"10.1177","volume":"34","author":[{"given":"Keisuke","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department 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