{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:33:14Z","timestamp":1777793594858,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Sch\u00f6nfeld and Reiser recently hypothesized that fatty acid \u03b2-oxidation is a source of oxidative stress in the brain. To test this hypothesis, we inhibited brain mitochondrial \u03b2-oxidation with methyl palmoxirate (MEP) and measured oxidative polyunsaturated fatty acid (PUFA) metabolites in the rat brain. Upon MEP treatment, levels of several nonenzymatic auto-oxidative PUFA metabolites were reduced with few effects on enzymatically derived metabolites. Our finding confirms the hypothesis that reduced fatty acid \u03b2-oxidation decreases oxidative stress in the brain and \u03b2-oxidation inhibitors may be a novel therapeutic approach for brain disorders associated with oxidative stress.<\/jats:p>","DOI":"10.1038\/jcbfm.2013.221","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T03:55:48Z","timestamp":1386734148000},"page":"376-379","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Inhibiting Mitochondrial\n                    <i>\u03b2<\/i>\n                    -Oxidation Selectively Reduces Levels of Nonenzymatic Oxidative Polyunsaturated Fatty Acid Metabolites in the Brain"],"prefix":"10.1177","volume":"34","author":[{"given":"Chuck T","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Olivier","family":"Tr\u00e9panier","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E","family":"Hopperton","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony F","family":"Domenichiello","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojgan","family":"Masoodi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Nestl\u00e9 Institute of Health Sciences SA, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P","family":"Bazinet","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"bibr1-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1042\/bj0300661"},{"key":"bibr2-jcbfm.2013.221","first-page":"1843","volume-title":"Handbook of Physiology Neurophysiology.","author":"Sokoloff L","year":"1960"},{"key":"bibr3-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00306-1"},{"key":"bibr4-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.04.016"},{"key":"bibr5-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.026203"},{"key":"bibr6-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.11.026"},{"key":"bibr7-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07116.x"},{"key":"bibr8-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.08.001"},{"key":"bibr9-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90101-9"},{"key":"bibr10-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.128"},{"key":"bibr11-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038505"},{"key":"bibr12-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D700030-JLR200"},{"key":"bibr13-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb00885.x"},{"key":"bibr14-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2668"},{"key":"bibr15-jcbfm.2013.221","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.10.021"}],"container-title":["Journal of Cerebral Blood Flow &amp; 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