{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:33:47Z","timestamp":1791660827942,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    Alzheimer's disease (AD) is characterized by age-dependent biochemical, metabolic, and physiologic changes. These age-dependent changes ultimately converge to impair cognitive functions. This study was carried out to examine the metabolic changes by probing glucose and tricarboxylic acid cycle metabolism in a 7-month-old triple transgenic mouse model of AD (3\u00d7Tg-AD). The effect of lipoic acid, an insulin-mimetic agent, was also investigated to examine its ability in modulating age-dependent metabolic changes. Seven-month-old 3\u00d7Tg-AD mice were given intravenous infusion of [1-\n                    <jats:sup>13<\/jats:sup>\n                    C]glucose followed by an ex vivo\n                    <jats:sup>13<\/jats:sup>\n                    C nuclear magnetic resonance to determine the concentrations of\n                    <jats:sup>13<\/jats:sup>\n                    C-labeled isotopomers of glutamate, glutamine, aspartate, gamma aminobutyric acid, and N-acetylaspartate. An intravenous infusion of [1-\n                    <jats:sup>13<\/jats:sup>\n                    C]glucose+[1,2-\n                    <jats:sup>13<\/jats:sup>\n                    C]acetate was given for different periods of time to distinguish neuronal and astrocytic metabolism. Enrichments of glutamate, glutamine, and aspartate were calculated after quantifying the total (\n                    <jats:sup>12<\/jats:sup>\n                    C+\n                    <jats:sup>13<\/jats:sup>\n                    C) concentrations by high-performance liquid chromatography. A hypermetabolic state was clearly evident in 7-month-old 3\u00d7Tg-AD mice in contrast to the hypometabolic state reported earlier in 13-month-old mice. Hypermetabolism was evidenced by prominent increase of\n                    <jats:sup>13<\/jats:sup>\n                    C labeling and enrichment in the 3\u00d7Tg-AD mice. Lipoic acid feeding to the hypermetabolic 3\u00d7Tg-AD mice brought the metabolic parameters to the levels of nonTg mice.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2014.137","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T09:12:58Z","timestamp":1407316378000},"page":"1749-1760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Hypermetabolic State in the 7-Month-Old Triple Transgenic Mouse Model of Alzheimer'S Disease and the Effect of Lipoic Acid: A\n                    <sup>13<\/sup>\n                    C-NMR Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Harsh","family":"Sancheti","sequence":"first","affiliation":[{"name":"Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, 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San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Cadenas","sequence":"additional","affiliation":[{"name":"Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, 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