{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:38:11Z","timestamp":1777793891548,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Pulsed arterial spin labeling (PASL) at multiple inflow times (multi-TIs) is advantageous for the measurement of brain perfusion in patients with long arterial transit times (ATTs) as in steno-occlusive disease, because bolus-arrival-time can be measured and blood flow measurements can be corrected accordingly. Owing to its increased signal-to-noise ratio, a combination with a three-dimensional gradient and spin echo (GRASE) readout allows acquiring a sufficient number of multi-TIs within a clinically feasible acquisition time of 5\u2009minutes. We compared this technique with the clinical standard dynamic susceptibility-weighted contrast-enhanced imaging\u2014magnetic resonance imaging in patients with unilateral stenosis &gt;70% of the internal carotid or middle cerebral artery (MCA) at 3 Tesla. We performed qualitative (assessment by three expert raters) and quantitative (region of interest (ROI)\/volume of interest (VOI) based) comparisons. In 43 patients, multi-TI PASL-GRASE showed perfusion alterations with moderate accuracy in the qualitative analysis. Quantitatively, moderate correlation coefficients were found for the MCA territory (ROI based: r=0.52, VOI based: r=0.48). In the anterior cerebral artery (ACA) territory, a readout related right-sided susceptibility artifact impaired correlation (ROI based: r=0.29, VOI based: r=0.34). Arterial transit delay artifacts were found only in 12% of patients. In conclusion, multi-TI PASL-GRASE can correct for arterial transit delay in patients with long ATTs. These results are promising for the transfer of ASL to the clinical practice.<\/jats:p>","DOI":"10.1038\/jcbfm.2014.200","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T04:36:53Z","timestamp":1416371813000},"page":"392-401","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["3D GRASE Pulsed Arterial Spin Labeling at Multiple Inflow Times in Patients with Long Arterial Transit Times: Comparison with Dynamic Susceptibility-Weighted Contrast-Enhanced MRI at 3 Tesla"],"prefix":"10.1177","volume":"35","author":[{"given":"Steve Z","family":"Martin","sequence":"first","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vince I","family":"Madai","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9\u2014Universtit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico C","family":"von Samson-Himmelstjerna","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"},{"name":"Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias A","family":"Mutke","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9\u2014Universtit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Bauer","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius X","family":"Herzig","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hetzer","sequence":"additional","affiliation":[{"name":"Berlin Center for Advanced Neuroimaging (BCAN), Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany"},{"name":"Faculty of Physics and Electronics, University of Bremen, Bremen, Germany"},{"name":"mediri GmbH, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sobesky","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9\u2014Universit\u00e4tsmedizin, Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9\u2014Universtit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"bibr1-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230106"},{"key":"bibr2-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23581"},{"key":"bibr3-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000177839.03321.25"},{"key":"bibr4-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.023"},{"key":"bibr5-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00703.x"},{"key":"bibr6-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004001"},{"key":"bibr7-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.06.017"},{"key":"bibr8-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2725"},{"key":"bibr9-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087143"},{"key":"bibr10-jcbfm.2014.200","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20580"},{"key":"bibr11-jcbfm.2014.200","unstructured":"Healthcare Siemenes Global Webside:2014 syngo ASL https:\/\/www.healthcare.siemens.com\/magnetic-resonance-imaging\/options-and-upgrades\/clinical-applications\/asl.htm."},{"key":"bibr12-jcbfm.2014.200","doi-asserted-by":"crossref","unstructured":"Alsop DC, Detre JA, Golay X, G\u00fcnther M, Hendrikse J, Hernandez-Garcia L, et al Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. 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