{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:05:18Z","timestamp":1778504718828,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Ethanol increases the interstitial dopamine (DA) concentration in the nucleus accumbens (NAcc) of experimental animals, but positron emission tomography (PET) studies using the single-bolus protocol of the [\n                    <jats:sup>11<\/jats:sup>\n                    C]-raclopride competition paradigm have yielded conflicting results in humans. To resolve disparate previous findings, we utilized the bolus-plus-infusion (B\/I) method, allowing both baseline and intervention quantification of [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride binding during a single 105-minute PET scan, to investigate possible ethanol-induced DA release in nine healthy male subjects. A 25-minute intravenous ethanol (7.6%) infusion, resulting in a 1.3\u2009g\/L mean blood ethanol concentration, was administered using masked timing during the PET scan. Automated region-of-interest analysis testing the difference between baseline (40\u201350 minutes) and intervention (60\u201385 minutes) revealed an average 12.6% decrease in [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride binding in the ventral striatum (VST, P=0.003) including the NAcc. In addition, a shorter time interval from the start of ethanol infusion to the first subjective effect was associated with a greater binding potential decrease bilaterally in the VST ( r=0.92, P=0.004), and the feeling of pleasure was associated with a decrease in binding potential values in both the caudate nucleus ( r=\u22120.87, P=0.003) and putamen ( r=\u22120.74; P=0.02). These results confirm that ethanol induces rapid DA release in the limbic striatum, which can be reliably estimated using the B\/I method in one imaging session.\n                  <\/jats:p>","DOI":"10.1038\/jcbfm.2014.209","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T03:57:15Z","timestamp":1418183835000},"page":"424-431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Intravenous Ethanol Increases Dopamine Release in the Ventral Striatum in Humans: PET Study Using Bolus-Plus-Infusion Administration of [\n                    <sup>11<\/sup>\n                    C]raclopride"],"prefix":"10.1177","volume":"35","author":[{"given":"Sargo","family":"Aalto","sequence":"first","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Department of Psychology, \u00c5bo Akademi University, \u00c5bo, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimmo","family":"Ingman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Alakurtti","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valtteri","family":"Kaasinen","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Virkkala","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Medical Imaging Centre, Pirkanmaa Hospital District, Tampere, 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