{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:38:42Z","timestamp":1793529522558,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.<\/jats:p>","DOI":"10.1038\/jcbfm.2014.212","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T03:56:12Z","timestamp":1417578972000},"page":"186-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["The Role of the Spleen in Ischemic Stroke"],"prefix":"10.1177","volume":"35","author":[{"given":"Keith R","family":"Pennypacker","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Offner","sequence":"additional","affiliation":[{"name":"Department of Neurology and Anesthesiology, Oregon Health and Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"bibr1-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.101"},{"key":"bibr2-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600217"},{"key":"bibr3-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6523"},{"key":"bibr4-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9283-0"},{"key":"bibr5-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.03.017"},{"key":"bibr6-jcbfm.2014.212","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.3760\/cma.j.issn.0366-6999.20122483","volume":"126","author":"Zhang BJ","year":"2013","journal-title":"Chin Med J"},{"key":"bibr7-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/759103"},{"key":"bibr8-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21661"},{"key":"bibr9-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0206-5"},{"key":"bibr10-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000633"},{"key":"bibr11-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm306"},{"key":"bibr12-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181f30fc9"},{"key":"bibr13-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-148"},{"key":"bibr14-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.07.005"},{"key":"bibr15-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1996.tb00726.x"},{"key":"bibr16-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02207.x"},{"key":"bibr17-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1007\/s001099900029"},{"key":"bibr18-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.03.024"},{"key":"bibr19-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00497-4"},{"key":"bibr20-jcbfm.2014.212","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.227454"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2014.212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/jcbfm.2014.212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/jcbfm.2014.212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:22Z","timestamp":1777493542000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/jcbfm.2014.212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1038\/jcbfm.2014.212"],"URL":"https:\/\/doi.org\/10.1038\/jcbfm.2014.212","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,3]]}}}