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Working with primary cultured neurons, as well as with genetically modified mice and flies, here we report that\u2014against general belief\u2014neurons contain a low but measurable amount of glycogen. Moreover, we also show that these cells express the brain isoform of glycogen Phosphorylase, allowing glycogen to be fully metabolized. Most importantly, we show an active neuronal glycogen metabolism that protects cultured neurons from hypoxia-induced death and flies from hypoxia-induced stupor. Our findings change the current view of the role of glycogen in the brain and reveal that endogenous neuronal glycogen metabolism participates in the neuronal tolerance to hypoxic stress.<\/jats:p>","DOI":"10.1038\/jcbfm.2014.33","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T04:02:57Z","timestamp":1393387377000},"page":"945-955","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":203,"title":["Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia"],"prefix":"10.1177","volume":"34","author":[{"given":"Isabel","family":"Saez","sequence":"first","affiliation":[{"name":"Iinstitute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, 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